Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 5581..6161 Replicon plasmid unnamed5
Accession NZ_CP106911
Organism Klebsiella pneumoniae strain BSIKPN-11

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag OE130_RS30910 Protein ID WP_071177730.1
Coordinates 5581..5895 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag OE130_RS30915 Protein ID WP_000093040.1
Coordinates 5883..6161 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OE130_RS30885 (OE130_30885) 1525..3489 + 1965 WP_071177727.1 TraM recognition domain-containing protein -
OE130_RS30890 (OE130_30890) 3489..4220 + 732 WP_071177728.1 MobC family replication-relaxation protein -
OE130_RS30895 (OE130_30895) 4227..4757 + 531 WP_071177729.1 hypothetical protein -
OE130_RS30900 (OE130_30900) 4784..4963 - 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
OE130_RS30905 (OE130_30905) 4989..5417 - 429 WP_001140599.1 hypothetical protein -
OE130_RS30910 (OE130_30910) 5581..5895 - 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OE130_RS30915 (OE130_30915) 5883..6161 - 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
OE130_RS30920 (OE130_30920) 6336..6701 - 366 WP_072354022.1 TonB family protein -
OE130_RS30925 (OE130_30925) 6698..7069 - 372 WP_001237044.1 cell envelope integrity protein TolA -
OE130_RS30930 (OE130_30930) 7343..7588 - 246 WP_032440458.1 hypothetical protein -
OE130_RS30935 (OE130_30935) 7915..9600 + 1686 WP_032440457.1 colicin-like bacteriocin tRNase domain-containing protein -
OE130_RS30940 (OE130_30940) 9610..9867 + 258 WP_032440455.1 colicin E3-like toxin immunity protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10060 10060


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T260010 WP_071177730.1 NZ_CP106911:c5895-5581 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT260010 WP_000093040.1 NZ_CP106911:c6161-5883 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References