Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5397206..5397831 Replicon chromosome
Accession NZ_CP106906
Organism Klebsiella pneumoniae strain BSIKPN-11

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag OE130_RS26735 Protein ID WP_002882817.1
Coordinates 5397206..5397589 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OE130_RS26740 Protein ID WP_004150355.1
Coordinates 5397589..5397831 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OE130_RS26720 (OE130_26720) 5394572..5395474 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
OE130_RS26725 (OE130_26725) 5395471..5396106 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OE130_RS26730 (OE130_26730) 5396103..5397032 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OE130_RS26735 (OE130_26735) 5397206..5397589 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
OE130_RS26740 (OE130_26740) 5397589..5397831 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OE130_RS26745 (OE130_26745) 5398036..5398953 + 918 WP_002882812.1 alpha/beta hydrolase -
OE130_RS26750 (OE130_26750) 5398967..5399908 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OE130_RS26755 (OE130_26755) 5399953..5400390 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OE130_RS26760 (OE130_26760) 5400387..5401247 - 861 WP_002882807.1 virulence factor BrkB family protein -
OE130_RS26765 (OE130_26765) 5401241..5401840 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T259997 WP_002882817.1 NZ_CP106906:c5397589-5397206 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT259997 WP_004150355.1 NZ_CP106906:c5397831-5397589 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References