Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5073154..5074835 Replicon chromosome
Accession NZ_CP106906
Organism Klebsiella pneumoniae strain BSIKPN-11

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag OE130_RS25230 Protein ID WP_002885155.1
Coordinates 5073154..5074071 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag OE130_RS25235 Protein ID WP_004151732.1
Coordinates 5074077..5074835 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OE130_RS25210 (OE130_25210) 5068460..5069980 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
OE130_RS25215 (OE130_25215) 5069977..5070975 + 999 WP_002885172.1 ribose ABC transporter permease -
OE130_RS25220 (OE130_25220) 5071006..5071947 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
OE130_RS25225 (OE130_25225) 5072022..5073029 + 1008 WP_004151731.1 carbohydrate kinase family protein -
OE130_RS25230 (OE130_25230) 5073154..5074071 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
OE130_RS25235 (OE130_25235) 5074077..5074835 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
OE130_RS25240 (OE130_25240) 5074921..5075649 - 729 WP_002885152.1 response regulator transcription factor -
OE130_RS25245 (OE130_25245) 5075922..5078069 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
OE130_RS25250 (OE130_25250) 5078299..5078985 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T259996 WP_002885155.1 NZ_CP106906:c5074071-5073154 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT259996 WP_004151732.1 NZ_CP106906:c5074835-5074077 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References