Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4916970..4917486 Replicon chromosome
Accession NZ_CP106906
Organism Klebsiella pneumoniae strain BSIKPN-11

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag OE130_RS24430 Protein ID WP_002886902.1
Coordinates 4916970..4917254 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OE130_RS24435 Protein ID WP_002886901.1
Coordinates 4917244..4917486 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OE130_RS24405 (OE130_24405) 4912454..4912717 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
OE130_RS24410 (OE130_24410) 4912847..4913020 + 174 WP_002886906.1 hypothetical protein -
OE130_RS24415 (OE130_24415) 4913023..4913766 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OE130_RS24420 (OE130_24420) 4914123..4916261 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
OE130_RS24425 (OE130_24425) 4916502..4916966 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OE130_RS24430 (OE130_24430) 4916970..4917254 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OE130_RS24435 (OE130_24435) 4917244..4917486 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OE130_RS24440 (OE130_24440) 4917564..4919474 - 1911 WP_004152270.1 PRD domain-containing protein -
OE130_RS24445 (OE130_24445) 4919497..4920651 - 1155 WP_002886900.1 lactonase family protein -
OE130_RS24450 (OE130_24450) 4920717..4921457 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T259995 WP_002886902.1 NZ_CP106906:c4917254-4916970 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT259995 WP_002886901.1 NZ_CP106906:c4917486-4917244 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References