Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4813677..4814487 Replicon chromosome
Accession NZ_CP106906
Organism Klebsiella pneumoniae strain BSIKPN-11

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag OE130_RS23935 Protein ID WP_002887280.1
Coordinates 4813677..4814210 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag OE130_RS23940 Protein ID WP_002887278.1
Coordinates 4814221..4814487 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OE130_RS23930 (OE130_23930) 4812508..4813629 + 1122 WP_002887282.1 cupin domain-containing protein -
OE130_RS23935 (OE130_23935) 4813677..4814210 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
OE130_RS23940 (OE130_23940) 4814221..4814487 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
OE130_RS23945 (OE130_23945) 4814590..4816023 - 1434 WP_002887275.1 Cu(+)/Ag(+) sensor histidine kinase -
OE130_RS23950 (OE130_23950) 4816013..4816696 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
OE130_RS23955 (OE130_23955) 4816868..4818253 + 1386 WP_002887267.1 efflux transporter outer membrane subunit -
OE130_RS23960 (OE130_23960) 4818271..4818615 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(91-151)

Antitoxin

(2-86)


Sequences


Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T259994 WP_002887280.1 NZ_CP106906:c4814210-4813677 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp


Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT259994 WP_002887278.1 NZ_CP106906:c4814487-4814221 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN


Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References