Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 32259..32998 Replicon plasmid unnamed2
Accession NZ_CP106896
Organism Enterobacter hormaechei strain EHX_PAT_001

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag N6139_RS24370 Protein ID WP_058675171.1
Coordinates 32513..32998 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A085GLQ4
Locus tag N6139_RS24365 Protein ID WP_032611697.1
Coordinates 32259..32525 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6139_RS24355 (N6139_24345) 27551..30517 + 2967 WP_001138064.1 Tn3-like element TnAs3 family transposase -
N6139_RS24360 (N6139_24350) 30668..31906 - 1239 WP_058675170.1 IS110 family transposase -
N6139_RS24365 (N6139_24355) 32259..32525 + 267 WP_032611697.1 DUF1778 domain-containing protein Antitoxin
N6139_RS24370 (N6139_24360) 32513..32998 + 486 WP_058675171.1 GNAT family N-acetyltransferase Toxin
N6139_RS24375 (N6139_24365) 33417..34106 + 690 Protein_32 ISNCY family transposase -
N6139_RS24380 (N6139_24370) 34170..35317 + 1148 Protein_33 IS3 family transposase -
N6139_RS24385 (N6139_24375) 35336..35944 - 609 Protein_34 DNA (cytosine-5-)-methyltransferase -
N6139_RS24390 (N6139_24380) 36350..37339 - 990 WP_058675112.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(A) / sul1 / qacE / aac(6')-Il / blaVIM-1 / blaTEM-1A / blaOXA-9 / ant(3'')-Ia / aac(6')-Ib - 1..156088 156088
- inside IScluster/Tn - - 10037..42325 32288


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17692.47 Da        Isoelectric Point: 9.8719

>T259981 WP_058675171.1 NZ_CP106896:32513-32998 [Enterobacter hormaechei]
VGHVTAPEPLSAFHQVAEFVSGETVLDDWLKQKGLKNQALGAARTFVVCKKDTKQIAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10164.64 Da        Isoelectric Point: 4.3837

>AT259981 WP_032611697.1 NZ_CP106896:32259-32525 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPIIEKLL
ARKPQWDM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A085GLQ4

References