Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 210650..211176 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP106895 | ||
| Organism | Enterobacter hormaechei strain EHX_PAT_001 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | N6139_RS23935 | Protein ID | WP_000323025.1 |
| Coordinates | 210650..210937 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | N6139_RS23940 | Protein ID | WP_000534858.1 |
| Coordinates | 210937..211176 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| N6139_RS23900 (N6139_23890) | 206220..206396 | - | 177 | WP_001371930.1 | hypothetical protein | - |
| N6139_RS23905 (N6139_23895) | 206907..207851 | + | 945 | WP_000778029.1 | DUF5417 domain-containing protein | - |
| N6139_RS23910 (N6139_23900) | 207947..208549 | + | 603 | WP_001371889.1 | hypothetical protein | - |
| N6139_RS23915 (N6139_23905) | 208609..208959 | + | 351 | WP_000743059.1 | hypothetical protein | - |
| N6139_RS23920 (N6139_23910) | 209006..209209 | + | 204 | WP_001015183.1 | hypothetical protein | - |
| N6139_RS23925 (N6139_23915) | 209491..209811 | + | 321 | WP_000332796.1 | hypothetical protein | - |
| N6139_RS23930 (N6139_23920) | 210424..210549 | - | 126 | WP_229020258.1 | DUF5431 family protein | - |
| N6139_RS23935 (N6139_23925) | 210650..210937 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| N6139_RS23940 (N6139_23930) | 210937..211176 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| N6139_RS23945 (N6139_23935) | 211201..211305 | + | 105 | Protein_221 | protein YdfV | - |
| N6139_RS23950 (N6139_23940) | 211439..212362 | - | 924 | WP_000167917.1 | cation diffusion facilitator family transporter | - |
| N6139_RS23955 (N6139_23945) | 212562..213134 | - | 573 | WP_001515348.1 | cytochrome b/b6 domain-containing protein | - |
| N6139_RS23960 (N6139_23950) | 213610..214848 | - | 1239 | WP_000219087.1 | IS110-like element ISEsa2 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaVIM-1 / aac(6')-Il / dfrA1 / aadA15 / qacE / sul1 / qnrA1 / dfrA16 / aadA2 / mcr-9 | - | 1..262065 | 262065 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T259980 WP_000323025.1 NZ_CP106895:c210937-210650 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T259980 NZ_CP106895:c210937-210650 [Enterobacter hormaechei]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT259980 WP_000534858.1 NZ_CP106895:c211176-210937 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT259980 NZ_CP106895:c211176-210937 [Enterobacter hormaechei]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|