Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3823051..3823708 Replicon chromosome
Accession NZ_CP106894
Organism Enterobacter hormaechei strain EHX_PAT_001

Toxin (Protein)


Gene name cptA Uniprot ID A0A837FG63
Locus tag N6139_RS18530 Protein ID WP_003863439.1
Coordinates 3823051..3823461 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag N6139_RS18535 Protein ID WP_003863437.1
Coordinates 3823442..3823708 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6139_RS18510 (N6139_18500) 3819049..3820782 - 1734 WP_022651808.1 single-stranded-DNA-specific exonuclease RecJ -
N6139_RS18515 (N6139_18505) 3820788..3821501 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N6139_RS18520 (N6139_18510) 3821530..3822426 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
N6139_RS18525 (N6139_18515) 3822528..3823049 + 522 WP_003863440.1 flavodoxin FldB -
N6139_RS18530 (N6139_18520) 3823051..3823461 - 411 WP_003863439.1 protein YgfX Toxin
N6139_RS18535 (N6139_18525) 3823442..3823708 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
N6139_RS18540 (N6139_18530) 3824003..3824983 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
N6139_RS18545 (N6139_18535) 3825069..3825728 - 660 WP_003863433.1 hemolysin III family protein -
N6139_RS18550 (N6139_18540) 3825995..3826726 + 732 WP_023314798.1 MurR/RpiR family transcriptional regulator -
N6139_RS18555 (N6139_18545) 3826843..3828276 + 1434 WP_003863430.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16339.24 Da        Isoelectric Point: 11.4775

>T259978 WP_003863439.1 NZ_CP106894:c3823461-3823051 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT259978 WP_003863437.1 NZ_CP106894:c3823708-3823442 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FG63

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References