Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 3124290..3126073 Replicon chromosome
Accession NZ_CP106894
Organism Enterobacter hormaechei strain EHX_PAT_001

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N6139_RS15075 Protein ID WP_023314540.1
Coordinates 3124290..3125639 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A837FFV9
Locus tag N6139_RS15080 Protein ID WP_003859317.1
Coordinates 3125636..3126073 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6139_RS15050 (N6139_15040) 3120113..3121048 - 936 WP_003859306.1 tRNA dihydrouridine(16) synthase DusC -
N6139_RS15055 (N6139_15045) 3121217..3121612 + 396 WP_003859308.1 CidA/LrgA family protein -
N6139_RS15060 (N6139_15050) 3121609..3122304 + 696 WP_003859310.1 CidB/LrgB family autolysis modulator -
N6139_RS15065 (N6139_15055) 3122433..3123317 + 885 WP_003859312.1 cytidine deaminase -
N6139_RS15070 (N6139_15060) 3123445..3124155 + 711 WP_003859314.1 outer membrane permeability protein SanA -
N6139_RS15075 (N6139_15065) 3124290..3125639 + 1350 WP_023314540.1 HipA domain-containing protein Toxin
N6139_RS15080 (N6139_15070) 3125636..3126073 + 438 WP_003859317.1 helix-turn-helix transcriptional regulator Antitoxin
N6139_RS15085 (N6139_15075) 3126112..3127122 - 1011 WP_003859318.1 galactose/methyl galactoside ABC transporter permease MglC -
N6139_RS15090 (N6139_15080) 3127138..3128658 - 1521 WP_003859320.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
N6139_RS15095 (N6139_15085) 3128738..3129736 - 999 WP_017383382.1 galactose/glucose ABC transporter substrate-binding protein MglB -
N6139_RS15100 (N6139_15090) 3130032..3131054 - 1023 WP_003859324.1 HTH-type transcriptional regulator GalS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51137.78 Da        Isoelectric Point: 4.6562

>T259977 WP_023314540.1 NZ_CP106894:3124290-3125639 [Enterobacter hormaechei]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL

Download         Length: 1350 bp

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16185.64 Da        Isoelectric Point: 10.5154

>AT259977 WP_003859317.1 NZ_CP106894:3125636-3126073 [Enterobacter hormaechei]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEEPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS

Download         Length: 438 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A837FFV9

References