Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2294582..2295321 Replicon chromosome
Accession NZ_CP106894
Organism Enterobacter hormaechei strain EHX_PAT_001

Toxin (Protein)


Gene name tacT Uniprot ID A0A837FFP9
Locus tag N6139_RS10965 Protein ID WP_032609220.1
Coordinates 2294582..2295067 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag N6139_RS10970 Protein ID WP_003857131.1
Coordinates 2295055..2295321 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6139_RS10935 (N6139_10930) 2290073..2290645 + 573 WP_045346197.1 NAD(P)H-dependent oxidoreductase -
N6139_RS10940 (N6139_10935) 2290648..2291667 + 1020 WP_045346198.1 aldo/keto reductase -
N6139_RS10945 (N6139_10940) 2291706..2292083 + 378 WP_023292403.1 DUF1330 domain-containing protein -
N6139_RS10950 (N6139_10945) 2292177..2292725 + 549 WP_058674708.1 NAD(P)H-dependent oxidoreductase -
N6139_RS10955 (N6139_10950) 2292766..2293461 + 696 WP_058674671.1 antibiotic biosynthesis monooxygenase -
N6139_RS10960 (N6139_10955) 2293477..2294280 + 804 WP_045346200.1 carboxymuconolactone decarboxylase family protein -
N6139_RS10965 (N6139_10960) 2294582..2295067 - 486 WP_032609220.1 GNAT family N-acetyltransferase Toxin
N6139_RS10970 (N6139_10965) 2295055..2295321 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
N6139_RS10975 (N6139_10970) 2295385..2296314 - 930 WP_045346202.1 LysR family transcriptional regulator -
N6139_RS10980 (N6139_10975) 2296444..2297832 + 1389 WP_058674672.1 MFS transporter -
N6139_RS10985 (N6139_10980) 2297854..2298849 - 996 WP_048240773.1 DUF2891 domain-containing protein -
N6139_RS10990 (N6139_10985) 2298859..2299845 - 987 WP_022651202.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(80-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17554.26 Da        Isoelectric Point: 9.9658

>T259972 WP_032609220.1 NZ_CP106894:c2295067-2294582 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVICKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT259972 WP_003857131.1 NZ_CP106894:c2295321-2295055 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References