Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1116023..1116643 Replicon chromosome
Accession NZ_CP106894
Organism Enterobacter hormaechei strain EHX_PAT_001

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag N6139_RS05185 Protein ID WP_015571250.1
Coordinates 1116023..1116241 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag N6139_RS05190 Protein ID WP_006809850.1
Coordinates 1116269..1116643 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6139_RS05155 (N6139_05155) 1112035..1112295 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
N6139_RS05160 (N6139_05160) 1112298..1112438 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
N6139_RS05165 (N6139_05165) 1112435..1113145 - 711 WP_022650493.1 GNAT family protein -
N6139_RS05170 (N6139_05170) 1113247..1114707 + 1461 WP_022650494.1 PLP-dependent aminotransferase family protein -
N6139_RS05175 (N6139_05175) 1114679..1115146 - 468 WP_022650495.1 YlaC family protein -
N6139_RS05180 (N6139_05180) 1115263..1115814 - 552 WP_022650496.1 maltose O-acetyltransferase -
N6139_RS05185 (N6139_05185) 1116023..1116241 - 219 WP_015571250.1 HHA domain-containing protein Toxin
N6139_RS05190 (N6139_05190) 1116269..1116643 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
N6139_RS05195 (N6139_05195) 1117154..1120300 - 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit AcrB -
N6139_RS05200 (N6139_05200) 1120323..1121516 - 1194 WP_058675313.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T259971 WP_015571250.1 NZ_CP106894:c1116241-1116023 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT259971 WP_006809850.1 NZ_CP106894:c1116643-1116269 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References