Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 298658..299254 Replicon chromosome
Accession NZ_CP106894
Organism Enterobacter hormaechei strain EHX_PAT_001

Toxin (Protein)


Gene name PumA Uniprot ID A0A837F9W8
Locus tag N6139_RS01440 Protein ID WP_023315213.1
Coordinates 298952..299254 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag N6139_RS01435 Protein ID WP_058674766.1
Coordinates 298658..298945 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6139_RS01430 (N6139_01430) 297030..298661 + 1632 WP_058674767.1 Na/Pi cotransporter family protein -
N6139_RS01435 (N6139_01435) 298658..298945 - 288 WP_058674766.1 putative addiction module antidote protein Antitoxin
N6139_RS01440 (N6139_01440) 298952..299254 - 303 WP_023315213.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N6139_RS01445 (N6139_01445) 299452..300324 + 873 WP_045346556.1 23S rRNA pseudouridine(2604) synthase RluF -
N6139_RS01450 (N6139_01450) 300325..300597 - 273 WP_003860346.1 DUF3811 domain-containing protein -
N6139_RS01455 (N6139_01455) 300648..301592 - 945 WP_045350764.1 ketopantoate/pantoate/pantothenate transporter PanS -
N6139_RS01460 (N6139_01460) 301686..303035 - 1350 WP_050871353.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11427.21 Da        Isoelectric Point: 10.1042

>T259970 WP_023315213.1 NZ_CP106894:c299254-298952 [Enterobacter hormaechei]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRVYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10060.54 Da        Isoelectric Point: 5.7807

>AT259970 WP_058674766.1 NZ_CP106894:c298945-298658 [Enterobacter hormaechei]
MHKLTPYDPASALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837F9W8

Antitoxin

Source ID Structure

References