Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 36012..36922 Replicon plasmid unnamed1
Accession NZ_CP106891
Organism Klebsiella pneumoniae strain KPN_SINK_001

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag N6138_RS27175 Protein ID WP_004883378.1
Coordinates 36452..36922 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag N6138_RS27170 Protein ID WP_004026357.1
Coordinates 36012..36455 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6138_RS27145 (N6138_27140) 31179..31394 - 216 Protein_41 IS200/IS605 family transposase -
N6138_RS27150 (N6138_27145) 31396..31965 + 570 Protein_42 transposase -
N6138_RS27155 (N6138_27150) 32333..33820 - 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -
N6138_RS27160 (N6138_27155) 34230..34652 + 423 WP_004181893.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
N6138_RS27165 (N6138_27160) 34652..35912 + 1261 Protein_45 translesion error-prone DNA polymerase V subunit UmuC -
N6138_RS27170 (N6138_27165) 36012..36455 + 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
N6138_RS27175 (N6138_27170) 36452..36922 + 471 WP_004883378.1 RES family NAD+ phosphorylase Toxin
N6138_RS27180 (N6138_27175) 37031..37291 - 261 WP_004026352.1 hypothetical protein -
N6138_RS27185 (N6138_27180) 38014..38172 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
N6138_RS27190 (N6138_27185) 38778..39752 + 975 WP_004883382.1 hypothetical protein -
N6138_RS27195 (N6138_27190) 39736..39858 + 123 WP_255308559.1 hypothetical protein -
N6138_RS27200 (N6138_27195) 39950..40327 - 378 WP_004883386.1 hypothetical protein -
N6138_RS27205 (N6138_27200) 40642..40854 + 213 WP_046654973.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..209198 209198
- flank IS/Tn - - 31612..31965 353


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17500.82 Da        Isoelectric Point: 4.6155

>T259966 WP_004883378.1 NZ_CP106891:36452-36922 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVLKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT259966 WP_004026357.1 NZ_CP106891:36012-36455 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References