Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4897233..4897749 Replicon chromosome
Accession NZ_CP106890
Organism Klebsiella pneumoniae strain KPN_SINK_001

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag N6138_RS24265 Protein ID WP_002886902.1
Coordinates 4897233..4897517 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag N6138_RS24270 Protein ID WP_002886901.1
Coordinates 4897507..4897749 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6138_RS24240 (N6138_24235) 4892717..4892980 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
N6138_RS24245 (N6138_24240) 4893110..4893283 + 174 WP_002886906.1 hypothetical protein -
N6138_RS24250 (N6138_24245) 4893286..4894029 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
N6138_RS24255 (N6138_24250) 4894386..4896524 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
N6138_RS24260 (N6138_24255) 4896765..4897229 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N6138_RS24265 (N6138_24260) 4897233..4897517 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N6138_RS24270 (N6138_24265) 4897507..4897749 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N6138_RS24275 (N6138_24270) 4897827..4899737 - 1911 WP_004152270.1 PRD domain-containing protein -
N6138_RS24280 (N6138_24275) 4899760..4900914 - 1155 WP_002886900.1 lactonase family protein -
N6138_RS24285 (N6138_24280) 4900980..4901720 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T259963 WP_002886902.1 NZ_CP106890:c4897517-4897233 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT259963 WP_002886901.1 NZ_CP106890:c4897749-4897507 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References