Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4794073..4794883 Replicon chromosome
Accession NZ_CP106890
Organism Klebsiella pneumoniae strain KPN_SINK_001

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag N6138_RS23770 Protein ID WP_002887280.1
Coordinates 4794073..4794606 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag N6138_RS23775 Protein ID WP_002887278.1
Coordinates 4794617..4794883 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6138_RS23765 (N6138_23760) 4792904..4794025 + 1122 WP_002887282.1 cupin domain-containing protein -
N6138_RS23770 (N6138_23765) 4794073..4794606 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
N6138_RS23775 (N6138_23770) 4794617..4794883 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
N6138_RS23780 (N6138_23775) 4794986..4796419 - 1434 WP_002887275.1 Cu(+)/Ag(+) sensor histidine kinase -
N6138_RS23785 (N6138_23780) 4796409..4797092 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
N6138_RS23790 (N6138_23785) 4797264..4798649 + 1386 WP_002887267.1 efflux transporter outer membrane subunit -
N6138_RS23795 (N6138_23790) 4798667..4799011 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T259962 WP_002887280.1 NZ_CP106890:c4794606-4794073 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT259962 WP_002887278.1 NZ_CP106890:c4794883-4794617 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References