Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2790656..2792244 Replicon chromosome
Accession NZ_CP106890
Organism Klebsiella pneumoniae strain KPN_SINK_001

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag N6138_RS13865 Protein ID WP_004199851.1
Coordinates 2790656..2791978 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag N6138_RS13870 Protein ID WP_002904790.1
Coordinates 2791978..2792244 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6138_RS13850 (N6138_13855) 2785721..2788222 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
N6138_RS13855 (N6138_13860) 2788210..2789214 + 1005 WP_004199852.1 fimbrial protein -
N6138_RS13860 (N6138_13865) 2789347..2790639 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
N6138_RS13865 (N6138_13870) 2790656..2791978 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
N6138_RS13870 (N6138_13875) 2791978..2792244 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
N6138_RS13875 (N6138_13880) 2792510..2792836 - 327 WP_002904788.1 hydroxyisourate hydrolase -
N6138_RS13880 (N6138_13885) 2792833..2793333 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
N6138_RS13885 (N6138_13890) 2793311..2794690 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
N6138_RS13890 (N6138_13895) 2795036..2796087 + 1052 Protein_2722 FAD-dependent urate hydroxylase HpxO -
N6138_RS13895 (N6138_13900) 2796068..2796991 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T259960 WP_004199851.1 NZ_CP106890:c2791978-2790656 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT259960 WP_002904790.1 NZ_CP106890:c2792244-2791978 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References