Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3339885..3340539 Replicon chromosome
Accession NC_016822
Organism Shigella sonnei 53G

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag SSON53G_RS17690 Protein ID WP_000244777.1
Coordinates 3339885..3340292 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag SSON53G_RS17695 Protein ID WP_000354046.1
Coordinates 3340273..3340539 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSON53G_RS17670 (3335842) 3335842..3337575 - 1734 WP_000813167.1 single-stranded-DNA-specific exonuclease RecJ -
SSON53G_RS17675 (3337581) 3337581..3338291 - 711 WP_000715206.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
SSON53G_RS17680 (3338316) 3338316..3339212 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
SSON53G_RS17685 (3339324) 3339324..3339845 + 522 WP_001055874.1 flavodoxin FldB -
SSON53G_RS17690 (3339885) 3339885..3340292 - 408 WP_000244777.1 protein YgfX Toxin
SSON53G_RS17695 (3340273) 3340273..3340539 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
SSON53G_RS17700 (3340782) 3340782..3341762 + 981 WP_000886060.1 tRNA-modifying protein YgfZ -
SSON53G_RS17705 (3341958) 3341958..3342617 - 660 WP_000250274.1 hemolysin III family protein -
SSON53G_RS17710 (3342781) 3342781..3343092 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
SSON53G_RS17715 (3343137) 3343137..3344570 + 1434 WP_005137189.1 6-phospho-beta-glucosidase BglA -
SSON53G_RS17720 (3344627) 3344627..3345370 - 744 WP_000951938.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T25996 WP_000244777.1 NC_016822:c3340292-3339885 [Shigella sonnei 53G]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T25996 NC_016822:c3340292-3339885 [Shigella sonnei 53G]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT25996 WP_000354046.1 NC_016822:c3340539-3340273 [Shigella sonnei 53G]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT25996 NC_016822:c3340539-3340273 [Shigella sonnei 53G]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References