Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 907440..908097 Replicon chromosome
Accession NZ_CP106890
Organism Klebsiella pneumoniae strain KPN_SINK_001

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag N6138_RS04630 Protein ID WP_002916310.1
Coordinates 907687..908097 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag N6138_RS04625 Protein ID WP_002916312.1
Coordinates 907440..907706 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6138_RS04600 (N6138_04600) 902596..904029 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
N6138_RS04605 (N6138_04605) 904148..904876 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
N6138_RS04610 (N6138_04610) 904926..905237 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
N6138_RS04615 (N6138_04615) 905401..906060 + 660 WP_002916317.1 hemolysin III family protein -
N6138_RS04620 (N6138_04620) 906211..907194 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
N6138_RS04625 (N6138_04625) 907440..907706 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
N6138_RS04630 (N6138_04630) 907687..908097 + 411 WP_002916310.1 protein YgfX Toxin
N6138_RS04635 (N6138_04635) 908104..908625 - 522 WP_002916308.1 flavodoxin FldB -
N6138_RS04640 (N6138_04640) 908726..909622 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
N6138_RS04645 (N6138_04645) 909645..910358 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N6138_RS04650 (N6138_04650) 910364..912097 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T259955 WP_002916310.1 NZ_CP106890:907687-908097 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT259955 WP_002916312.1 NZ_CP106890:907440-907706 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References