Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 4897039..4897555 | Replicon | chromosome |
Accession | NZ_CP106886 | ||
Organism | Klebsiella pneumoniae strain KPN_PAT_001 |
Toxin (Protein)
Gene name | relE | Uniprot ID | J2XDK6 |
Locus tag | N6137_RS24265 | Protein ID | WP_002886902.1 |
Coordinates | 4897039..4897323 (-) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | R4Y888 |
Locus tag | N6137_RS24270 | Protein ID | WP_002886901.1 |
Coordinates | 4897313..4897555 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
N6137_RS24240 (N6137_24235) | 4892523..4892786 | - | 264 | WP_004152271.1 | PTS sugar transporter subunit IIB | - |
N6137_RS24245 (N6137_24240) | 4892916..4893089 | + | 174 | WP_002886906.1 | hypothetical protein | - |
N6137_RS24250 (N6137_24245) | 4893092..4893835 | + | 744 | WP_002886905.1 | MurR/RpiR family transcriptional regulator | - |
N6137_RS24255 (N6137_24250) | 4894192..4896330 | + | 2139 | WP_002886904.1 | anaerobic ribonucleoside-triphosphate reductase | - |
N6137_RS24260 (N6137_24255) | 4896571..4897035 | + | 465 | WP_002886903.1 | anaerobic ribonucleoside-triphosphate reductase-activating protein | - |
N6137_RS24265 (N6137_24260) | 4897039..4897323 | - | 285 | WP_002886902.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
N6137_RS24270 (N6137_24265) | 4897313..4897555 | - | 243 | WP_002886901.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
N6137_RS24275 (N6137_24270) | 4897633..4899543 | - | 1911 | WP_004152270.1 | PRD domain-containing protein | - |
N6137_RS24280 (N6137_24275) | 4899566..4900720 | - | 1155 | WP_002886900.1 | lactonase family protein | - |
N6137_RS24285 (N6137_24280) | 4900786..4901526 | - | 741 | WP_002886899.1 | KDGP aldolase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11125.95 Da Isoelectric Point: 10.3787
>T259946 WP_002886902.1 NZ_CP106886:c4897323-4897039 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
Download Length: 285 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GMH2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GLP0 |