Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4793886..4794696 Replicon chromosome
Accession NZ_CP106886
Organism Klebsiella pneumoniae strain KPN_PAT_001

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag N6137_RS23775 Protein ID WP_002887280.1
Coordinates 4793886..4794419 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag N6137_RS23780 Protein ID WP_002887278.1
Coordinates 4794430..4794696 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6137_RS23770 (N6137_23765) 4792717..4793838 + 1122 WP_002887282.1 cupin domain-containing protein -
N6137_RS23775 (N6137_23770) 4793886..4794419 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
N6137_RS23780 (N6137_23775) 4794430..4794696 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
N6137_RS23785 (N6137_23780) 4794799..4796232 - 1434 WP_002887275.1 Cu(+)/Ag(+) sensor histidine kinase -
N6137_RS23790 (N6137_23785) 4796222..4796905 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
N6137_RS23795 (N6137_23790) 4797077..4798462 + 1386 WP_002887267.1 efflux transporter outer membrane subunit -
N6137_RS23800 (N6137_23795) 4798480..4798824 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T259945 WP_002887280.1 NZ_CP106886:c4794419-4793886 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT259945 WP_002887278.1 NZ_CP106886:c4794696-4794430 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References