Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4180133..4180752 Replicon chromosome
Accession NZ_CP106886
Organism Klebsiella pneumoniae strain KPN_PAT_001

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag N6137_RS20825 Protein ID WP_002892050.1
Coordinates 4180534..4180752 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag N6137_RS20820 Protein ID WP_002892066.1
Coordinates 4180133..4180507 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6137_RS20810 (N6137_20805) 4175285..4176478 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N6137_RS20815 (N6137_20810) 4176501..4179647 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
N6137_RS20820 (N6137_20815) 4180133..4180507 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
N6137_RS20825 (N6137_20820) 4180534..4180752 + 219 WP_002892050.1 HHA domain-containing protein Toxin
N6137_RS20830 (N6137_20825) 4180911..4181477 + 567 WP_002892030.1 maltose O-acetyltransferase -
N6137_RS20835 (N6137_20830) 4181449..4181589 - 141 WP_004147370.1 hypothetical protein -
N6137_RS20840 (N6137_20835) 4181610..4182080 + 471 WP_002892026.1 YlaC family protein -
N6137_RS20845 (N6137_20840) 4182055..4183506 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
N6137_RS20850 (N6137_20845) 4183607..4184305 + 699 WP_002892021.1 GNAT family protein -
N6137_RS20855 (N6137_20850) 4184302..4184442 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
N6137_RS20860 (N6137_20855) 4184442..4184705 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T259944 WP_002892050.1 NZ_CP106886:4180534-4180752 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT259944 WP_002892066.1 NZ_CP106886:4180133-4180507 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References