Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5900038..5900662 Replicon chromosome
Accession NZ_CP106885
Organism Achromobacter spanius strain LIG3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag N8Z00_RS26520 Protein ID WP_268079350.1
Coordinates 5900038..5900220 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N8Z00_RS26525 Protein ID WP_268079351.1
Coordinates 5900270..5900662 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8Z00_RS26490 (N8Z00_26490) 5895850..5896719 - 870 WP_268079346.1 alpha/beta hydrolase -
N8Z00_RS26495 (N8Z00_26495) 5896970..5897887 - 918 WP_268079347.1 DUF808 domain-containing protein -
N8Z00_RS26500 (N8Z00_26500) 5898080..5898337 - 258 WP_259251979.1 hypothetical protein -
N8Z00_RS26505 (N8Z00_26505) 5898406..5898609 - 204 WP_050448526.1 cold-shock protein -
N8Z00_RS26510 (N8Z00_26510) 5899072..5899509 + 438 WP_268079348.1 hypothetical protein -
N8Z00_RS26515 (N8Z00_26515) 5899528..5899869 - 342 WP_268079349.1 hypothetical protein -
N8Z00_RS26520 (N8Z00_26520) 5900038..5900220 + 183 WP_268079350.1 type II toxin-antitoxin system HicA family toxin Toxin
N8Z00_RS26525 (N8Z00_26525) 5900270..5900662 + 393 WP_268079351.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N8Z00_RS26530 (N8Z00_26530) 5900703..5901443 - 741 WP_268079352.1 SDR family oxidoreductase -
N8Z00_RS26535 (N8Z00_26535) 5901481..5902818 - 1338 WP_268082501.1 CitMHS family transporter -
N8Z00_RS26540 (N8Z00_26540) 5903011..5903715 + 705 WP_268079353.1 response regulator transcription factor -
N8Z00_RS26545 (N8Z00_26545) 5903719..5905173 + 1455 WP_268079354.1 sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6765.99 Da        Isoelectric Point: 12.1585

>T259934 WP_268079350.1 NZ_CP106885:5900038-5900220 [Achromobacter spanius]
MNSREIIRQLRQAGWVFRHAKGSHHIFVHPQKPGHISVPHPKKDLGIGLVTKLLTQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13915.77 Da        Isoelectric Point: 4.2687

>AT259934 WP_268079351.1 NZ_CP106885:5900270-5900662 [Achromobacter spanius]
MKYPIAIEPGSETQAWGVVVPDLPGCFSAADSGIDEAIENAKEAIELWIETALDSGTPVPVATSIAGHQANPEFAGWIWA
IVEIDPAVMDDTIERINITLPRRILARIDAKARAAGESRSGYIAHLALTH

Download         Length: 393 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References