Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 565316..566933 Replicon chromosome
Accession NZ_CP106885
Organism Achromobacter spanius strain LIG3

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N8Z00_RS02455 Protein ID WP_268080213.1
Coordinates 565316..566629 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N8Z00_RS02460 Protein ID WP_268080214.1
Coordinates 566673..566933 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8Z00_RS02435 (N8Z00_02435) 560872..562299 + 1428 WP_268080207.1 basic amino acid/polyamine antiporter -
N8Z00_RS02440 (N8Z00_02440) 562317..564140 + 1824 WP_268080209.1 SLC13 family permease -
N8Z00_RS02445 (N8Z00_02445) 564265..564744 + 480 WP_268080211.1 hypothetical protein -
N8Z00_RS02450 (N8Z00_02450) 564794..565285 + 492 WP_268080212.1 hypothetical protein -
N8Z00_RS02455 (N8Z00_02455) 565316..566629 - 1314 WP_268080213.1 type II toxin-antitoxin system HipA family toxin Toxin
N8Z00_RS02460 (N8Z00_02460) 566673..566933 - 261 WP_268080214.1 helix-turn-helix transcriptional regulator Antitoxin
N8Z00_RS02465 (N8Z00_02465) 567120..568217 - 1098 WP_268080215.1 DUF3396 domain-containing protein -
N8Z00_RS02470 (N8Z00_02470) 568226..568867 - 642 WP_268080216.1 VRR-NUC domain-containing protein -
N8Z00_RS02475 (N8Z00_02475) 568864..569370 - 507 WP_268080217.1 PAAR domain-containing protein -
N8Z00_RS02480 (N8Z00_02480) 569423..569854 - 432 Protein_482 integrase core domain-containing protein -
N8Z00_RS02485 (N8Z00_02485) 570135..570815 - 681 WP_268080218.1 hypothetical protein -
N8Z00_RS02490 (N8Z00_02490) 571391..571786 - 396 WP_268080220.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 560272..571786 11514


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(1-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 48540.60 Da        Isoelectric Point: 6.7741

>T259929 WP_268080213.1 NZ_CP106885:c566629-565316 [Achromobacter spanius]
MNGEFVGTWSVQPHVGEVLQYADAWVASGQGRPLSLSLPFTPGNPPHRGEAVRTYFENLLPDSKEIRERVARRYQAGSTN
AFALLAEVGRDCVGALQVVPGPDAPDGVQEVNAVPMTDAEIAQLLRNTLAPGPLGRNAAEDEDFRISIAGAQEKSAMLWY
DGRWCRPHGATPTTHIFKLPLGLVANMKFDMSDSVENEWLCSEILRAYQMPVARTEPLMFEDMKVLAVERFDRMWWESPE
GKRWLIRLPQEDMCQATATPPHLKYESDGGPGVRQIMKLLATSRAPDRDRRTFFQAQVLFWMLRATDGHAKNFSIFLRQG
GTYELTPLYDVLSAYPVIGKGAKKLSPYDAKMAMAVRSKNPHWVMRDILRRHWIAVGTEHGVVNPDGKGVEHVLDDLVAR
TPGVVKAVRALLPAGFPMHVADCILNGLQEAADHLAG

Download         Length: 1314 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9398.77 Da        Isoelectric Point: 8.8776

>AT259929 WP_268080214.1 NZ_CP106885:c566933-566673 [Achromobacter spanius]
MTDFTVRTAEQLPALLQGFRKQSGLTQADTAMRLGVSQQALSHLERHADKVSADRLLELLSILGVELVLRKTSESPSPKA
SVGPNW

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References