Detailed information of TA system TA025992

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 1746411..1746895
• Replicon: chromosome
• Accession: NC_016822
• Organism: Shigella sonnei 53G

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A377EAU1
• Locus tag: SSON53G_RS09205
• Protein ID: WP_014334020.1
• Coordinates: 1746605..1746895 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: A0A376K4R9
• Locus tag: SSON53G_RS09200
• Protein ID: WP_005142544.1
• Coordinates: 1746411..1746605 (+)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SSON53G_RS09160 (1741606)	1741606..1741962	-	357	WP_005140877.1	hypothetical protein	-
SSON53G_RS09165 (1742020)	1742020..1742442	-	423	WP_001151171.1	DUF977 family protein	-
SSON53G_RS31955 (1742458)	1742458..1743183	-	726	WP_000450631.1	DUF1627 domain-containing protein	-
SSON53G_RS31960 (1743205)	1743205..1743951	-	747	WP_000788740.1	ATP-binding protein	-
SSON53G_RS09180 (1743958)	1743958..1745022	-	1065	WP_001262380.1	hypothetical protein	-
SSON53G_RS09185 (1745094)	1745094..1745519	-	426	WP_000693826.1	toxin YdaT family protein	-
SSON53G_RS29065 (1745516)	1745516..1745779	-	264	WP_001048456.1	helix-turn-helix transcriptional regulator	-
SSON53G_RS09195 (1745906)	1745906..1746391	+	486	WP_053002468.1	helix-turn-helix domain-containing protein	-
SSON53G_RS09200 (1746411)	1746411..1746605	+	195	WP_005142544.1	hypothetical protein	Antitoxin
SSON53G_RS09205 (1746605)	1746605..1746895	+	291	WP_014334020.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SSON53G_RS09210 (1747174)	1747174..1747326	+	153	WP_000379558.1	DUF1391 family protein	-
SSON53G_RS09215 (1747338)	1747338..1747703	+	366	WP_024174355.1	hypothetical protein	-
SSON53G_RS09225 (1749081)	1749081..1749869	+	789	WP_000935603.1	Rha family phage regulatory protein	-
SSON53G_RS34435 (1750617)	1750617..1750712	+	96	Protein_1748	transcriptional regulator	-
SSON53G_RS09235 (1750723)	1750723..1750911	+	189	WP_000449206.1	cell division inhibition protein DicB	-
SSON53G_RS09240 (1750908)	1750908..1751099	+	192	WP_001090204.1	DUF1482 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	sodB / rhs/PAAR / rhs/PAAR / vgrG/tssI	1634899..1872289	237390

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11062.93 Da
• Isoelectric Point: 10.2013

>T25992 WP_014334020.1 NC_016822:1746605-1746895 [Shigella sonnei 53G]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS

Nucleotide

• Length: 291 bp

>T25992 NC_016822:1746605-1746895 [Shigella sonnei 53G]
ATGTTACCCGTTTTATGGCTACCATCTGCTCGTGATGATTTGCGCCAGATCGTAGCCTACATAGCTAAAGAAAATCCCGC
GGCAGCACGCAGAATGAAAATTCGAATTGAAACATCCGTTTTGCCGCTCACAGAGCATCCTTACCTGTATCCTCCAAGCG
AGCGAGTTCTTGGTCTTCGTGAAATTGTAACTCATCCTAACTACATCATCCTTTACCGAGTAACAGCATCAAGCATAGAA
GTAGTAAATATTGTGCATTCTCGAAGACAGTATCCAGGCAAAAACAGTTAA

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7097.98 Da
• Isoelectric Point: 4.1759

>AT25992 WP_005142544.1 NC_016822:1746411-1746605 [Shigella sonnei 53G]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE

Nucleotide

• Length: 195 bp

>AT25992 NC_016822:1746411-1746605 [Shigella sonnei 53G]
ATGAGTACAGTCCTTTCCCCAATGGTTTCAGAATTTGAGACAGTTGAGCAAGAAAATAGTTACAACGAATGGCTGCGGGC
CAAAGTAGCAGCAAGCCTCGCGGATCCCCGCCCGGCGATTCCGCATGATGAGGTAATGGCGGAAATGGAACAAATTATTG
CCCAAATTGCTGCTGCAACTCACAGAGGTGAATAA

Structures

Toxin

• AlphaFold DB: A0A377EAU1

Antitoxin

• AlphaFold DB: A0A376K4R9