Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 2214877..2215541 Replicon chromosome
Accession NZ_CP106873
Organism Mycobacterium avium subsp. paratuberculosis K-10

Toxin (Protein)


Gene name vapC Uniprot ID Q73YC9
Locus tag OBK31_RS10515 Protein ID WP_003872398.1
Coordinates 2214877..2215284 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q73YC8
Locus tag OBK31_RS10520 Protein ID WP_003872399.1
Coordinates 2215281..2215541 (-) Length 87 a.a.

Genomic Context

OBK31_RS10490OBK31_RS10510OBK31_RS10530OBK31_RS10495OBK31_RS10500OBK31_RS10505OBK31_RS10515OBK31_RS10520OBK31_RS10525OBK31_RS10535OBK31_RS10540
Location: 2210077..2211246 (1170 bp)
Type: Others
Protein ID: WP_003878212.1
Location: 2213186..2214730 (1545 bp)
Type: Others
Protein ID: WP_010949452.1
Location: 2216340..2217608 (1269 bp)
Type: Others
Protein ID: WP_003872401.1
Location: 2211235..2211765 (531 bp)
Type: Others
Protein ID: WP_003878213.1
Location: 2211886..2212431 (546 bp)
Type: Others
Protein ID: WP_003878214.1
Location: 2212428..2212949 (522 bp)
Type: Others
Protein ID: WP_003878215.1
Location: 2214877..2215284 (408 bp)
Type: Toxin
Protein ID: WP_003872398.1
Location: 2215281..2215541 (261 bp)
Type: Antitoxin
Protein ID: WP_003872399.1
Location: 2215722..2216174 (453 bp)
Type: Others
Protein ID: WP_003872400.1
Location: 2217810..2219267 (1458 bp)
Type: Others
Protein ID: WP_003878220.1
Location: 2219463..2220125 (663 bp)
Type: Others
Protein ID: WP_003872403.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
OBK31_RS10490 (OBK31_10490)2210077..2211246+1170WP_003878212.1hypothetical protein-
OBK31_RS10495 (OBK31_10495)2211235..2211765-531WP_003878213.1TetR/AcrR family transcriptional regulator-
OBK31_RS10500 (OBK31_10500)2211886..2212431-546WP_003878214.1carboxymuconolactone decarboxylase family protein-
OBK31_RS10505 (OBK31_10505)2212428..2212949-522WP_003878215.1carboxymuconolactone decarboxylase family protein-
OBK31_RS10510 (OBK31_10510)2213186..2214730+1545WP_010949452.1serine/threonine-protein kinase-
OBK31_RS10515 (OBK31_10515)2214877..2215284-408WP_003872398.1type II toxin-antitoxin system VapC family toxinToxin
OBK31_RS10520 (OBK31_10520)2215281..2215541-261WP_003872399.1type II toxin-antitoxin system prevent-host-death family antitoxinAntitoxin
OBK31_RS10525 (OBK31_10525)2215722..2216174-453WP_003872400.1VOC family protein-
OBK31_RS10530 (OBK31_10530)2216340..2217608+1269WP_003872401.1cytochrome P450-
OBK31_RS10535 (OBK31_10535)2217810..2219267-1458WP_003878220.1serine/threonine-protein kinase-
OBK31_RS10540 (OBK31_10540)2219463..2220125-663WP_003872403.1TetR/AcrR family transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-64)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14418.47 Da        Isoelectric Point: 4.5642

>T259917 WP_003872398.1 NZ_CP106873:c2215284-2214877 [Mycobacterium avium subsp. paratuberculosis K-10]
MTARPAAGVLDTSVFIASESGRQLDEARIPDEVATTVVTLAELHAGVLAATTSNVRAQRLATLESIADMEMLPVDDDAVR
MWARLRIHLAEAGRRMRANDLWIAAIAASRGLPVVTQDDDFAALDGAANLAIIRV

Download         Length: 408 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9635.01 Da        Isoelectric Point: 11.7137

>AT259917 WP_003872399.1 NZ_CP106873:c2215541-2215281 [Mycobacterium avium subsp. paratuberculosis K-10]
MSEVASRELRNDTAGVLRRVREGEDVTITINGRAVAMLTPLRPQRRRWLSKAELLSRLRRAQADPGLRQDLATLAGDTTE
DLGPIR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7L5MIC8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7L5MIC5

References