Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 2214877..2215541 Replicon chromosome
Accession NZ_CP106873
Organism Mycobacterium avium subsp. paratuberculosis K-10

Toxin (Protein)


Gene name vapC Uniprot ID Q73YC9
Locus tag OBK31_RS10515 Protein ID WP_003872398.1
Coordinates 2214877..2215284 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q73YC8
Locus tag OBK31_RS10520 Protein ID WP_003872399.1
Coordinates 2215281..2215541 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OBK31_RS10490 (OBK31_10490) 2210077..2211246 + 1170 WP_003878212.1 hypothetical protein -
OBK31_RS10495 (OBK31_10495) 2211235..2211765 - 531 WP_003878213.1 TetR/AcrR family transcriptional regulator -
OBK31_RS10500 (OBK31_10500) 2211886..2212431 - 546 WP_003878214.1 carboxymuconolactone decarboxylase family protein -
OBK31_RS10505 (OBK31_10505) 2212428..2212949 - 522 WP_003878215.1 carboxymuconolactone decarboxylase family protein -
OBK31_RS10510 (OBK31_10510) 2213186..2214730 + 1545 WP_010949452.1 serine/threonine-protein kinase -
OBK31_RS10515 (OBK31_10515) 2214877..2215284 - 408 WP_003872398.1 type II toxin-antitoxin system VapC family toxin Toxin
OBK31_RS10520 (OBK31_10520) 2215281..2215541 - 261 WP_003872399.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
OBK31_RS10525 (OBK31_10525) 2215722..2216174 - 453 WP_003872400.1 VOC family protein -
OBK31_RS10530 (OBK31_10530) 2216340..2217608 + 1269 WP_003872401.1 cytochrome P450 -
OBK31_RS10535 (OBK31_10535) 2217810..2219267 - 1458 WP_003878220.1 serine/threonine-protein kinase -
OBK31_RS10540 (OBK31_10540) 2219463..2220125 - 663 WP_003872403.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-64)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14418.47 Da        Isoelectric Point: 4.5642

>T259917 WP_003872398.1 NZ_CP106873:c2215284-2214877 [Mycobacterium avium subsp. paratuberculosis K-10]
MTARPAAGVLDTSVFIASESGRQLDEARIPDEVATTVVTLAELHAGVLAATTSNVRAQRLATLESIADMEMLPVDDDAVR
MWARLRIHLAEAGRRMRANDLWIAAIAASRGLPVVTQDDDFAALDGAANLAIIRV

Download         Length: 408 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9635.01 Da        Isoelectric Point: 11.7137

>AT259917 WP_003872399.1 NZ_CP106873:c2215541-2215281 [Mycobacterium avium subsp. paratuberculosis K-10]
MSEVASRELRNDTAGVLRRVREGEDVTITINGRAVAMLTPLRPQRRRWLSKAELLSRLRRAQADPGLRQDLATLAGDTTE
DLGPIR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L5MIC8

Antitoxin

Source ID Structure
AlphaFold DB A0A7L5MIC5

References