Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/ParD(antitoxin) |
| Location | 1918190..1919188 | Replicon | chromosome |
| Accession | NZ_CP106873 | ||
| Organism | Mycobacterium avium subsp. paratuberculosis K-10 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | X7VT18 |
| Locus tag | OBK31_RS09225 | Protein ID | WP_003876749.1 |
| Coordinates | 1918190..1918768 (-) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | Q73Z26 |
| Locus tag | OBK31_RS09230 | Protein ID | WP_003878042.1 |
| Coordinates | 1918799..1919188 (-) | Length | 130 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OBK31_RS09200 (OBK31_09200) | 1914189..1915121 | - | 933 | Protein_1817 | sigma-70 family RNA polymerase sigma factor | - |
| OBK31_RS09205 (OBK31_09205) | 1915283..1915633 | + | 351 | WP_003878038.1 | DoxX family protein | - |
| OBK31_RS09210 (OBK31_09210) | 1915647..1916447 | - | 801 | WP_003876746.1 | nuclear transport factor 2 family protein | - |
| OBK31_RS09215 (OBK31_09215) | 1916447..1917007 | - | 561 | WP_003878040.1 | pyrazinamidase PncA | - |
| OBK31_RS09220 (OBK31_09220) | 1917118..1918185 | + | 1068 | WP_010949354.1 | DoxX family protein | - |
| OBK31_RS09225 (OBK31_09225) | 1918190..1918768 | - | 579 | WP_003876749.1 | zeta toxin family protein | Toxin |
| OBK31_RS09230 (OBK31_09230) | 1918799..1919188 | - | 390 | WP_003878042.1 | hypothetical protein | Antitoxin |
| OBK31_RS09235 (OBK31_09235) | 1919269..1919763 | - | 495 | WP_010949355.1 | gluconokinase | - |
| OBK31_RS09240 (OBK31_09240) | 1919760..1921757 | - | 1998 | WP_003876752.1 | phosphotransferase | - |
| OBK31_RS09245 (OBK31_09245) | 1921776..1923293 | - | 1518 | WP_015632643.1 | carboxylesterase/lipase family protein | - |
| OBK31_RS09250 (OBK31_09250) | 1923373..1924053 | + | 681 | WP_010949357.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21034.18 Da Isoelectric Point: 10.6678
>T259916 WP_003876749.1 NZ_CP106873:c1918768-1918190 [Mycobacterium avium subsp. paratuberculosis K-10]
MERLDVVVGPNGAGKSTFIALTLAPLLPGSVVVNADEIARQRWPQDPASHAYDAAKVAADTRAKLIDLGRSFIAETVFSH
PSKLDLLHAARRAGFTVVLHVLLIPEDLAVERVRHRVRAGGHDVPETKIRERHRRLWTPVAEAMTLADLATGYDNSRLRG
PRVVARLSGGLTVGAVDWPAWAPETLRSRWPV
MERLDVVVGPNGAGKSTFIALTLAPLLPGSVVVNADEIARQRWPQDPASHAYDAAKVAADTRAKLIDLGRSFIAETVFSH
PSKLDLLHAARRAGFTVVLHVLLIPEDLAVERVRHRVRAGGHDVPETKIRERHRRLWTPVAEAMTLADLATGYDNSRLRG
PRVVARLSGGLTVGAVDWPAWAPETLRSRWPV
Download Length: 579 bp
Antitoxin
Download Length: 130 a.a. Molecular weight: 13569.99 Da Isoelectric Point: 5.6717
>AT259916 WP_003878042.1 NZ_CP106873:c1919188-1918799 [Mycobacterium avium subsp. paratuberculosis K-10]
MAEAVDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGRLSTAEITAEEGVVFNAEI
SAAIDESLARTNYGATLAGQGVTTVALNDDGEIVEHRPDGTAVVLAGRR
MAEAVDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGRLSTAEITAEEGVVFNAEI
SAAIDESLARTNYGATLAGQGVTTVALNDDGEIVEHRPDGTAVVLAGRR
Download Length: 390 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E2W6B4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U6EQJ5 |