259915

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 850742..851395 Replicon chromosome
Accession NZ_CP106873
Organism Mycobacterium avium subsp. paratuberculosis K-10

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag OBK31_RS04360 Protein ID WP_003872880.1
Coordinates 850934..851395 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID Q742J1
Locus tag OBK31_RS04355 Protein ID WP_003872881.1
Coordinates 850742..850930 (+) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OBK31_RS04345 (OBK31_04345) 846724..848310 + 1587 WP_003872883.1 serine hydrolase -
OBK31_RS04350 (OBK31_04350) 848307..850679 + 2373 WP_003872882.1 HAD-IC family P-type ATPase -
OBK31_RS04355 (OBK31_04355) 850742..850930 + 189 WP_003872881.1 antitoxin Antitoxin
OBK31_RS04360 (OBK31_04360) 850934..851395 + 462 WP_003872880.1 SRPBCC family protein Toxin
OBK31_RS04365 (OBK31_04365) 851464..851898 + 435 WP_003877359.1 hypothetical protein -
OBK31_RS04370 (OBK31_04370) 852894..854477 + 1584 WP_003872878.1 DUF4185 domain-containing protein -
OBK31_RS04375 (OBK31_04375) 854517..854903 + 387 WP_003872877.1 hypothetical protein -
OBK31_RS04380 (OBK31_04380) 854938..855156 - 219 WP_016705560.1 hypothetical protein -
OBK31_RS04385 (OBK31_04385) 855692..856030 + 339 WP_016705559.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(2-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-51)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 16626.19 Da        Isoelectric Point: 9.5654

>T259915 WP_003872880.1 NZ_CP106873:850934-851395 [Mycobacterium avium subsp. paratuberculosis K-10]
VAKLSGSIDVPLPPEVAWQHASDLSRYKEWLTIHRVWRSTLPDQIDKGTVVESIVEVKGMLNRIKWTVVRYKPPEGMTLN
GDGVGGVKVKLMAKVQPKADGSVVSFDVHLGGPALFGPIGMIVAAALRGDIDQSLENFVTVFARSDPSTNGHR

Download         Length: 462 bp

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6745.42 Da        Isoelectric Point: 4.4865

>AT259915 WP_003872881.1 NZ_CP106873:850742-850930 [Mycobacterium avium subsp. paratuberculosis K-10]
MGFLDKAKDLLSQNADKVEMAIDKAGEFVDEKTQGKYSDTIHQVQEQAKKATGATETGDQQG

Download         Length: 189 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2WC18

References