Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 4309588..4310000 Replicon chromosome
Accession NZ_CP106869
Organism Xanthomonas sp. AM6

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag OCJ37_RS18415 Protein ID WP_263111139.1
Coordinates 4309806..4310000 (-) Length 65 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0K3A7Y3
Locus tag OCJ37_RS18410 Protein ID WP_053841641.1
Coordinates 4309588..4309800 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCJ37_RS18400 (OCJ37_18400) 4306339..4307304 - 966 WP_263111137.1 hypothetical protein -
OCJ37_RS18405 (OCJ37_18405) 4307756..4309312 - 1557 WP_263111138.1 SIR2 family protein -
OCJ37_RS18410 (OCJ37_18410) 4309588..4309800 - 213 WP_053841641.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OCJ37_RS18415 (OCJ37_18415) 4309806..4310000 - 195 WP_263111139.1 type II toxin-antitoxin system HicA family toxin Toxin
OCJ37_RS18420 (OCJ37_18420) 4310112..4312802 - 2691 WP_263111140.1 pyruvate dehydrogenase (acetyl-transferring), homodimeric type -
OCJ37_RS18425 (OCJ37_18425) 4313067..4314977 + 1911 WP_263113733.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4294379..4310000 15621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-62)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-62)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 6973.04 Da        Isoelectric Point: 11.0837

>T259912 WP_263111139.1 NZ_CP106869:c4310000-4309806 [Xanthomonas sp. AM6]
MPPKIRDVLQQLKDAGWQQVGQAGSHRQFKHPVYPGRVTVAGKPSDDVAPGTLNSILKQAGLKR

Download         Length: 195 bp

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7421.35 Da        Isoelectric Point: 3.8598

>AT259912 WP_053841641.1 NZ_CP106869:c4309800-4309588 [Xanthomonas sp. AM6]
MRYAVVIEQAGNNYSAYVPDLPGCVATGATTAEVEGLIREAIELHLAGMREDGEVIPLPSSQVEYVDVAA

Download         Length: 213 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0K3A7Y3

References