Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3186830..3187493 Replicon chromosome
Accession NZ_CP106852
Organism Edwardsiella ictaluri strain E9-302

Toxin (Protein)


Gene name cptA Uniprot ID C5BAS3
Locus tag N8I67_RS15040 Protein ID WP_015872556.1
Coordinates 3186830..3187246 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID C5BAS4
Locus tag N8I67_RS15045 Protein ID WP_015872557.1
Coordinates 3187227..3187493 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8I67_RS15020 (N8I67_15020) 3182754..3184487 - 1734 WP_015872552.1 single-stranded-DNA-specific exonuclease RecJ -
N8I67_RS15025 (N8I67_15025) 3184492..3185208 - 717 WP_015872553.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N8I67_RS15030 (N8I67_15030) 3185236..3186135 - 900 WP_015872554.1 site-specific tyrosine recombinase XerD -
N8I67_RS15035 (N8I67_15035) 3186293..3186805 + 513 WP_015872555.1 flavodoxin FldB -
N8I67_RS15040 (N8I67_15040) 3186830..3187246 - 417 WP_015872556.1 protein YgfX Toxin
N8I67_RS15045 (N8I67_15045) 3187227..3187493 - 267 WP_015872557.1 FAD assembly factor SdhE Antitoxin
N8I67_RS15050 (N8I67_15050) 3187841..3188836 + 996 WP_015872558.1 tRNA-modifying protein YgfZ -
N8I67_RS15055 (N8I67_15055) 3188877..3189701 - 825 WP_015872559.1 shikimate 5-dehydrogenase -
N8I67_RS15060 (N8I67_15060) 3189863..3190735 - 873 WP_015872560.1 nucleoside-specific channel-forming protein Tsx -
N8I67_RS15065 (N8I67_15065) 3191344..3191994 + 651 WP_035609190.1 hemolysin III family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16145.89 Da        Isoelectric Point: 11.3233

>T259907 WP_015872556.1 NZ_CP106852:c3187246-3186830 [Edwardsiella ictaluri]
VALWRCNVHASWRTQVMFLLGHGALVLAILLAPWPENYSVFWLILLVAVIFECIRSQRLIARNSGELQRLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGTPCRRRLWLAADSMSREEWGQLRRALLDTGDDRV

Download         Length: 417 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10364.92 Da        Isoelectric Point: 5.6951

>AT259907 WP_015872557.1 NZ_CP106852:c3187493-3187227 [Edwardsiella ictaluri]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLSCDDPELFKWLMNQGKPDDTDLARMITLIQTRN
KERGPLAL

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C5BAS3

Antitoxin

Source ID Structure
AlphaFold DB C5BAS4

References