Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1951359..1951881 Replicon chromosome
Accession NZ_CP106852
Organism Edwardsiella ictaluri strain E9-302

Toxin (Protein)


Gene name relE Uniprot ID C5BBL4
Locus tag N8I67_RS09200 Protein ID WP_015871319.1
Coordinates 1951600..1951881 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C5BBL3
Locus tag N8I67_RS09195 Protein ID WP_015871318.1
Coordinates 1951359..1951610 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8I67_RS09165 (N8I67_09165) 1946515..1947177 - 663 WP_015871312.1 hypothetical protein -
N8I67_RS09170 (N8I67_09170) 1947177..1947737 - 561 WP_263115783.1 hypothetical protein -
N8I67_RS09175 (N8I67_09175) 1947758..1948201 - 444 WP_015871314.1 hypothetical protein -
N8I67_RS09180 (N8I67_09180) 1948243..1948638 - 396 WP_049640651.1 hypothetical protein -
N8I67_RS09185 (N8I67_09185) 1948796..1950052 - 1257 WP_198077050.1 N4-gp56 family major capsid protein -
N8I67_RS09190 (N8I67_09190) 1950070..1951071 - 1002 WP_015871317.1 hypothetical protein -
N8I67_RS09195 (N8I67_09195) 1951359..1951610 + 252 WP_015871318.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N8I67_RS09200 (N8I67_09200) 1951600..1951881 + 282 WP_015871319.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N8I67_RS09205 (N8I67_09205) 1951953..1954067 - 2115 WP_015871320.1 hypothetical protein -
N8I67_RS09210 (N8I67_09210) 1954064..1955725 - 1662 WP_050977403.1 terminase -
N8I67_RS09215 (N8I67_09215) 1955718..1956140 - 423 WP_232347283.1 hypothetical protein -
N8I67_RS09220 (N8I67_09220) 1956275..1956502 - 228 WP_232347284.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1927647..1985438 57791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10783.62 Da        Isoelectric Point: 10.6993

>T259903 WP_015871319.1 NZ_CP106852:1951600-1951881 [Edwardsiella ictaluri]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNEVYQAADSR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9155.24 Da        Isoelectric Point: 3.7550

>AT259903 WP_015871318.1 NZ_CP106852:1951359-1951610 [Edwardsiella ictaluri]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVNI
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C5BBL4

Antitoxin

Source ID Structure
AlphaFold DB C5BBL3

References