259902

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1109815..1110407 Replicon chromosome
Accession NZ_CP106852
Organism Edwardsiella ictaluri strain E9-302

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag N8I67_RS05165 Protein ID WP_012847872.1
Coordinates 1109815..1110018 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C5BCY7
Locus tag N8I67_RS05170 Protein ID WP_015870487.1
Coordinates 1110039..1110407 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8I67_RS05125 (N8I67_05125) 1105035..1105496 + 462 WP_015870480.1 Lrp/AsnC family transcriptional regulator -
N8I67_RS05130 (N8I67_05130) 1105525..1105692 - 168 WP_015870481.1 hypothetical protein -
N8I67_RS05135 (N8I67_05135) 1105795..1106133 + 339 WP_015870482.1 P-II family nitrogen regulator -
N8I67_RS05140 (N8I67_05140) 1106155..1107435 + 1281 WP_198077273.1 ammonium transporter AmtB -
N8I67_RS05145 (N8I67_05145) 1107469..1108335 - 867 WP_015870484.1 acyl-CoA thioesterase II -
N8I67_RS05150 (N8I67_05150) 1108381..1108710 - 330 WP_015870485.1 MGMT family protein -
N8I67_RS05160 (N8I67_05160) 1109688..1109795 + 108 Protein_990 IS5/IS1182 family transposase -
N8I67_RS05165 (N8I67_05165) 1109815..1110018 - 204 WP_012847872.1 HHA domain-containing protein Toxin
N8I67_RS05170 (N8I67_05170) 1110039..1110407 - 369 WP_015870487.1 Hha toxicity modulator TomB Antitoxin
N8I67_RS05175 (N8I67_05175) 1110767..1113919 - 3153 WP_015870488.1 efflux RND transporter permease subunit -
N8I67_RS05180 (N8I67_05180) 1113963..1115147 - 1185 WP_015870489.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T259902 WP_012847872.1 NZ_CP106852:c1110018-1109815 [Edwardsiella ictaluri]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14287.03 Da        Isoelectric Point: 5.4786

>AT259902 WP_015870487.1 NZ_CP106852:c1110407-1110039 [Edwardsiella ictaluri]
MDENTSYQHDISELKYLCDYLYHQGIDVLGESNHGWVSDPTAEVNLQLNELIEHIASIAQSFKIKYPRHSDLAEMLDYYL
DETYALFGTYSISETALRQWLRTKRRMAYCLAHEKRNAALHV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB C5BCY7

References