259901

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 889392..890055 Replicon chromosome
Accession NZ_CP106852
Organism Edwardsiella ictaluri strain E9-302

Toxin (Protein)


Gene name tad Uniprot ID C5B7U4
Locus tag N8I67_RS04160 Protein ID WP_015870280.1
Coordinates 889711..890055 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag N8I67_RS04155 Protein ID WP_015870279.1
Coordinates 889392..889709 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8I67_RS04110 (N8I67_04110) 884723..885271 + 549 WP_015870271.1 YaeQ family protein -
N8I67_RS04115 (N8I67_04115) 885273..885689 + 417 WP_015870272.1 alternative ribosome rescue aminoacyl-tRNA hydrolase ArfB -
N8I67_RS04120 (N8I67_04120) 885786..886463 + 678 WP_015870273.1 envelope stress response activation lipoprotein NlpE -
N8I67_RS04125 (N8I67_04125) 886485..886745 - 261 WP_015870274.1 YfhL family 4Fe-4S dicluster ferredoxin -
N8I67_RS04130 (N8I67_04130) 887350..887628 + 279 WP_133175613.1 hypothetical protein -
N8I67_RS04140 (N8I67_04140) 888573..888752 + 180 WP_071525714.1 hypothetical protein -
N8I67_RS04145 (N8I67_04145) 888857..888985 + 129 WP_015870277.1 hypothetical protein -
N8I67_RS04150 (N8I67_04150) 888982..889359 + 378 WP_015870278.1 type II toxin-antitoxin system death-on-curing family toxin -
N8I67_RS04155 (N8I67_04155) 889392..889709 - 318 WP_015870279.1 helix-turn-helix transcriptional regulator Antitoxin
N8I67_RS04160 (N8I67_04160) 889711..890055 - 345 WP_015870280.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N8I67_RS04165 (N8I67_04165) 890227..890445 - 219 WP_232347353.1 head completion/stabilization protein -
N8I67_RS04170 (N8I67_04170) 890474..891163 + 690 WP_015870281.1 phage portal protein -
N8I67_RS04175 (N8I67_04175) 892291..893138 - 848 Protein_795 MurR/RpiR family transcriptional regulator -
N8I67_RS04180 (N8I67_04180) 893294..893938 + 645 WP_226092411.1 phosphatidylglycerophosphatase C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 888982..902049 13067


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-86)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12544.34 Da        Isoelectric Point: 9.8474

>T259901 WP_015870280.1 NZ_CP106852:c890055-889711 [Edwardsiella ictaluri]
MKSLYWVGSTKKDLQSLPEEVQDIFGYALHLAQVGGKHSQTKPLKGFSGAGVLEVVEDFLGDTYRAVYTVKFGDAVYVSH
VFQKKSSSGIATPKLNMDKIRERLKAAENHARGA

Download         Length: 345 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11480.41 Da        Isoelectric Point: 10.2058

>AT259901 WP_015870279.1 NZ_CP106852:c889709-889392 [Edwardsiella ictaluri]
MSHDIEVSSGNVYVDIGRDDAEEMLLKAQLATTIGNIIKSRSLTQEQAAKLLGMTQPKLSNMLRGQFRGISEAKMLECLT
RLGRDVQIVVGKPRRTPGSVKVVLA

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C5B7U4

Antitoxin

Source ID Structure

References