Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1951742..1952264 Replicon chromosome
Accession NZ_CP106849
Organism Edwardsiella ictaluri strain 669

Toxin (Protein)


Gene name relE Uniprot ID C5BBL4
Locus tag N8I66_RS09205 Protein ID WP_015871319.1
Coordinates 1951983..1952264 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C5BBL3
Locus tag N8I66_RS09200 Protein ID WP_015871318.1
Coordinates 1951742..1951993 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8I66_RS09170 (N8I66_09170) 1946898..1947560 - 663 WP_015871312.1 hypothetical protein -
N8I66_RS09175 (N8I66_09175) 1947560..1948120 - 561 WP_263115783.1 hypothetical protein -
N8I66_RS09180 (N8I66_09180) 1948141..1948584 - 444 WP_015871314.1 hypothetical protein -
N8I66_RS09185 (N8I66_09185) 1948626..1949021 - 396 WP_049640651.1 hypothetical protein -
N8I66_RS09190 (N8I66_09190) 1949179..1950435 - 1257 WP_198077050.1 N4-gp56 family major capsid protein -
N8I66_RS09195 (N8I66_09195) 1950453..1951454 - 1002 WP_015871317.1 hypothetical protein -
N8I66_RS09200 (N8I66_09200) 1951742..1951993 + 252 WP_015871318.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N8I66_RS09205 (N8I66_09205) 1951983..1952264 + 282 WP_015871319.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N8I66_RS09210 (N8I66_09210) 1952336..1954450 - 2115 WP_015871320.1 hypothetical protein -
N8I66_RS09215 (N8I66_09215) 1954447..1956108 - 1662 WP_050977403.1 terminase -
N8I66_RS09220 (N8I66_09220) 1956101..1956523 - 423 WP_232347283.1 hypothetical protein -
N8I66_RS09225 (N8I66_09225) 1956658..1956885 - 228 WP_232347284.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1928030..1985821 57791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10783.62 Da        Isoelectric Point: 10.6993

>T259895 WP_015871319.1 NZ_CP106849:1951983-1952264 [Edwardsiella ictaluri]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNEVYQAADSR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9155.24 Da        Isoelectric Point: 3.7550

>AT259895 WP_015871318.1 NZ_CP106849:1951742-1951993 [Edwardsiella ictaluri]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVNI
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C5BBL4

Antitoxin

Source ID Structure
AlphaFold DB C5BBL3

References