259894

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1109813..1110405 Replicon chromosome
Accession NZ_CP106849
Organism Edwardsiella ictaluri strain 669

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag N8I66_RS05170 Protein ID WP_012847872.1
Coordinates 1109813..1110016 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C5BCY7
Locus tag N8I66_RS05175 Protein ID WP_015870487.1
Coordinates 1110037..1110405 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8I66_RS05130 (N8I66_05130) 1105033..1105494 + 462 WP_015870480.1 Lrp/AsnC family transcriptional regulator -
N8I66_RS05135 (N8I66_05135) 1105523..1105690 - 168 WP_015870481.1 hypothetical protein -
N8I66_RS05140 (N8I66_05140) 1105793..1106131 + 339 WP_015870482.1 P-II family nitrogen regulator -
N8I66_RS05145 (N8I66_05145) 1106153..1107433 + 1281 WP_198077273.1 ammonium transporter AmtB -
N8I66_RS05150 (N8I66_05150) 1107467..1108333 - 867 WP_015870484.1 acyl-CoA thioesterase II -
N8I66_RS05155 (N8I66_05155) 1108379..1108708 - 330 WP_015870485.1 MGMT family protein -
N8I66_RS05165 (N8I66_05165) 1109686..1109793 + 108 Protein_991 IS5/IS1182 family transposase -
N8I66_RS05170 (N8I66_05170) 1109813..1110016 - 204 WP_012847872.1 HHA domain-containing protein Toxin
N8I66_RS05175 (N8I66_05175) 1110037..1110405 - 369 WP_015870487.1 Hha toxicity modulator TomB Antitoxin
N8I66_RS05180 (N8I66_05180) 1110765..1113917 - 3153 WP_015870488.1 efflux RND transporter permease subunit -
N8I66_RS05185 (N8I66_05185) 1113961..1115145 - 1185 WP_015870489.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T259894 WP_012847872.1 NZ_CP106849:c1110016-1109813 [Edwardsiella ictaluri]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14287.03 Da        Isoelectric Point: 5.4786

>AT259894 WP_015870487.1 NZ_CP106849:c1110405-1110037 [Edwardsiella ictaluri]
MDENTSYQHDISELKYLCDYLYHQGIDVLGESNHGWVSDPTAEVNLQLNELIEHIASIAQSFKIKYPRHSDLAEMLDYYL
DETYALFGTYSISETALRQWLRTKRRMAYCLAHEKRNAALHV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB C5BCY7

References