259893

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 889390..890053 Replicon chromosome
Accession NZ_CP106849
Organism Edwardsiella ictaluri strain 669

Toxin (Protein)


Gene name tad Uniprot ID C5B7U4
Locus tag N8I66_RS04160 Protein ID WP_015870280.1
Coordinates 889709..890053 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag N8I66_RS04155 Protein ID WP_015870279.1
Coordinates 889390..889707 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8I66_RS04110 (N8I66_04110) 884721..885269 + 549 WP_015870271.1 YaeQ family protein -
N8I66_RS04115 (N8I66_04115) 885271..885687 + 417 WP_015870272.1 alternative ribosome rescue aminoacyl-tRNA hydrolase ArfB -
N8I66_RS04120 (N8I66_04120) 885784..886461 + 678 WP_015870273.1 envelope stress response activation lipoprotein NlpE -
N8I66_RS04125 (N8I66_04125) 886483..886743 - 261 WP_015870274.1 YfhL family 4Fe-4S dicluster ferredoxin -
N8I66_RS04130 (N8I66_04130) 887348..887626 + 279 WP_133175613.1 hypothetical protein -
N8I66_RS04140 (N8I66_04140) 888571..888750 + 180 WP_071525714.1 hypothetical protein -
N8I66_RS04145 (N8I66_04145) 888855..888983 + 129 WP_015870277.1 hypothetical protein -
N8I66_RS04150 (N8I66_04150) 888980..889357 + 378 WP_015870278.1 type II toxin-antitoxin system death-on-curing family toxin -
N8I66_RS04155 (N8I66_04155) 889390..889707 - 318 WP_015870279.1 helix-turn-helix transcriptional regulator Antitoxin
N8I66_RS04160 (N8I66_04160) 889709..890053 - 345 WP_015870280.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N8I66_RS04165 (N8I66_04165) 890225..890443 - 219 WP_232347353.1 head completion/stabilization protein -
N8I66_RS04170 (N8I66_04170) 890472..891161 + 690 WP_015870281.1 phage portal protein -
N8I66_RS04175 (N8I66_04175) 892289..893136 - 848 Protein_795 MurR/RpiR family transcriptional regulator -
N8I66_RS04180 (N8I66_04180) 893292..893936 + 645 WP_226092411.1 phosphatidylglycerophosphatase C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 888980..902047 13067


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-86)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12544.34 Da        Isoelectric Point: 9.8474

>T259893 WP_015870280.1 NZ_CP106849:c890053-889709 [Edwardsiella ictaluri]
MKSLYWVGSTKKDLQSLPEEVQDIFGYALHLAQVGGKHSQTKPLKGFSGAGVLEVVEDFLGDTYRAVYTVKFGDAVYVSH
VFQKKSSSGIATPKLNMDKIRERLKAAENHARGA

Download         Length: 345 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11480.41 Da        Isoelectric Point: 10.2058

>AT259893 WP_015870279.1 NZ_CP106849:c889707-889390 [Edwardsiella ictaluri]
MSHDIEVSSGNVYVDIGRDDAEEMLLKAQLATTIGNIIKSRSLTQEQAAKLLGMTQPKLSNMLRGQFRGISEAKMLECLT
RLGRDVQIVVGKPRRTPGSVKVVLA

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C5B7U4

Antitoxin

Source ID Structure

References