Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2332213..2333826 Replicon chromosome
Accession NZ_CP106841
Organism Paenalcaligenes faecalis strain YLCF04

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N7U67_RS11050 Protein ID WP_269900686.1
Coordinates 2332213..2333562 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N7U67_RS11055 Protein ID WP_269900687.1
Coordinates 2333566..2333826 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7U67_RS11025 2327712..2328113 - 402 WP_269900682.1 hypothetical protein -
N7U67_RS11030 2328116..2328823 - 708 WP_269900683.1 hypothetical protein -
N7U67_RS11035 2328813..2329643 - 831 WP_269900684.1 hypothetical protein -
N7U67_RS11040 2330072..2330320 - 249 Protein_2153 transposase -
N7U67_RS11045 2330350..2331726 - 1377 WP_269900685.1 integrase family protein -
N7U67_RS11050 2332213..2333562 - 1350 WP_269900686.1 type II toxin-antitoxin system HipA family toxin Toxin
N7U67_RS11055 2333566..2333826 - 261 WP_269900687.1 helix-turn-helix transcriptional regulator Antitoxin
N7U67_RS11060 2334339..2334776 - 438 WP_269900688.1 hypothetical protein -
N7U67_RS11065 2334965..2336086 + 1122 WP_269900689.1 diguanylate cyclase -
N7U67_RS11070 2336102..2337070 - 969 WP_269900690.1 chemotaxis protein -
N7U67_RS11075 2337166..2337654 - 489 WP_269900691.1 hypothetical protein -
N7U67_RS11080 2337654..2338202 - 549 WP_269900692.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 50043.20 Da        Isoelectric Point: 6.5764

>T259891 WP_269900686.1 NZ_CP106841:c2333562-2332213 [Paenalcaligenes faecalis]
MGRRSHTQTLYLWMNGYFVGTWSVRPYTGDILQYDEGWVVSEHGRPLSLSLPFTPGNPPHRGDAVRTYFENLLPDSEDIL
KRVARRFQASSTGAFALLAEIGRDCVGALQILPDNVPPEGVQEVSATPLTDAEVAQVLRNTLASVSLIQGSDDVDFRISI
AGAQEKTALSWLNGQWCLPHGATPTTHIFKLPLGLVGNLRFDMSDSVENEWLCSKILHAYGLPVASTQILEFEDMKVLAV
ERFDRMWWENEEGKRWLLRIPQEDMCQATGTPPYLKYESDGGPGVRTIMKLLATSRDPDRDRRTFFQAQVLFWMLSATDG
HAKNFSIFLRPEGTYELTPLYDVLSAYPVIGKGANQLSPFKAKLAMAVRSKNPHWVMRDILRRHWLAVGAEHGVVAPDGR
GAEAVLDDLVAKTPEVVRAVRALLPKRFPEHVADSILNGLQLAANKLTG

Download         Length: 1350 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9467.93 Da        Isoelectric Point: 10.3016

>AT259891 WP_269900687.1 NZ_CP106841:c2333826-2333566 [Paenalcaligenes faecalis]
MTDFTIRTADQLPLMLQAFRKQANLTQTDVAMRLGVTQQTLSALERNAKKVSAERLLELLSILGVELVLRQNSDAPSPKP
STGSGW

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References