Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 163755..164506 Replicon plasmid unnamed
Accession NZ_CP106839
Organism Klebsiella michiganensis strain K5-3

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag N6B35_RS29130 Protein ID WP_263075199.1
Coordinates 164024..164506 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID W9B1S8
Locus tag N6B35_RS29125 Protein ID WP_016529519.1
Coordinates 163755..164033 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6B35_RS29110 (N6B35_29110) 160864..161355 + 492 WP_263075196.1 hypothetical protein -
N6B35_RS29115 (N6B35_29115) 161589..161903 - 315 WP_263075197.1 hypothetical protein -
N6B35_RS29120 (N6B35_29120) 162911..163447 - 537 WP_263075198.1 hypothetical protein -
N6B35_RS29125 (N6B35_29125) 163755..164033 + 279 WP_016529519.1 DUF1778 domain-containing protein Antitoxin
N6B35_RS29130 (N6B35_29130) 164024..164506 + 483 WP_263075199.1 GNAT family N-acetyltransferase Toxin
N6B35_RS29135 (N6B35_29135) 164544..164948 + 405 WP_263075200.1 DUF2251 domain-containing protein -
N6B35_RS29140 (N6B35_29140) 165285..166118 + 834 WP_263075201.1 GIY-YIG nuclease family protein -
N6B35_RS29145 (N6B35_29145) 166232..166381 + 150 WP_263075202.1 bacteriocin immunity protein -
N6B35_RS29150 (N6B35_29150) 166475..166711 - 237 WP_032416774.1 hypothetical protein -
N6B35_RS29155 (N6B35_29155) 167752..168480 + 729 WP_080929193.1 hypothetical protein -
N6B35_RS29160 (N6B35_29160) 168564..168737 + 174 Protein_176 EcsC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..301524 301524


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(6-92)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17785.72 Da        Isoelectric Point: 9.4946

>T259890 WP_263075199.1 NZ_CP106839:164024-164506 [Klebsiella michiganensis]
MGMRTPEPLTPEHNIAEFCCQDQVLSEWLKKKALKNHRTGISRVFVVCAENTNRVIAYYCLASGSVHRNTVPGAYRRNAP
EALPVIVLGRLAVDAAWARKGLGAALLKDAIYRTEHIAIQVGVRALLVHALNDEVREFYTKFGFEPSIANALTLLFPIKT

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10708.23 Da        Isoelectric Point: 4.5156

>AT259890 WP_016529519.1 NZ_CP106839:163755-164033 [Klebsiella michiganensis]
MKPDIREAPINIRAKTSQRDLIDMAANLVSKSRTDFMLEVACREAQDILLDQRLFLLDDNQFNAFVEELDAPMTPERQAR
IDNLMSRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W9B1S8

References