259889

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-DnaT
Location 124739..125261 Replicon plasmid unnamed
Accession NZ_CP106839
Organism Klebsiella michiganensis strain K5-3

Toxin (Protein)


Gene name stbE Uniprot ID -
Locus tag N6B35_RS28920 Protein ID WP_263075371.1
Coordinates 124739..125023 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID -
Locus tag N6B35_RS28925 Protein ID WP_263075372.1
Coordinates 125013..125261 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6B35_RS28890 (N6B35_28890) 120713..121837 + 1125 WP_263075368.1 N-acetyltransferase -
N6B35_RS28895 (N6B35_28895) 122057..122422 + 366 WP_263075369.1 diacylglycerol kinase -
N6B35_RS28900 (N6B35_28900) 122514..123416 + 903 WP_263075370.1 LysR family transcriptional regulator -
N6B35_RS28905 (N6B35_28905) 123409..124196 - 788 Protein_125 substrate-binding domain-containing protein -
N6B35_RS28910 (N6B35_28910) 124224..124549 - 326 Protein_126 citrate-proton symporter -
N6B35_RS28915 (N6B35_28915) 124539..124643 + 105 Protein_127 transposase -
N6B35_RS28920 (N6B35_28920) 124739..125023 - 285 WP_263075371.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N6B35_RS28925 (N6B35_28925) 125013..125261 - 249 WP_263075372.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N6B35_RS28930 (N6B35_28930) 125542..126663 - 1122 Protein_130 transposase -
N6B35_RS28935 (N6B35_28935) 126782..127360 - 579 WP_263075373.1 DUF4755 domain-containing protein -
N6B35_RS28940 (N6B35_28940) 127949..129133 - 1185 WP_263075374.1 cupin -
N6B35_RS28945 (N6B35_28945) 129144..129926 - 783 WP_263075375.1 aldolase/citrate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..301524 301524
- inside IScluster/Tn - - 124488..126588 2100


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10847.53 Da        Isoelectric Point: 10.2847

>T259889 WP_263075371.1 NZ_CP106839:c125023-124739 [Klebsiella michiganensis]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNSRVPASQLHGRQDQYKIKLCGAGCRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9056.35 Da        Isoelectric Point: 3.9421

>AT259889 WP_263075372.1 NZ_CP106839:c125261-125013 [Klebsiella michiganensis]
MAFQILTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELFEDQELGRIADERIGEALIEVRID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References