Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 85783..86360 Replicon plasmid unnamed
Accession NZ_CP106839
Organism Klebsiella michiganensis strain K5-3

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag N6B35_RS28720 Protein ID WP_263075339.1
Coordinates 85783..86115 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag N6B35_RS28725 Protein ID WP_263075340.1
Coordinates 86115..86360 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6B35_RS28705 (N6B35_28705) 83042..84031 + 990 WP_072002161.1 S8 family serine peptidase -
N6B35_RS28710 (N6B35_28710) 84358..85437 - 1080 WP_004220208.1 IS481-like element ISKpn28 family transposase -
N6B35_RS28715 (N6B35_28715) 85535..85642 + 108 WP_263075338.1 hypothetical protein -
N6B35_RS28720 (N6B35_28720) 85783..86115 - 333 WP_263075339.1 endoribonuclease MazF Toxin
N6B35_RS28725 (N6B35_28725) 86115..86360 - 246 WP_263075340.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
N6B35_RS28730 (N6B35_28730) 87456..87671 + 216 WP_263075341.1 hypothetical protein -
N6B35_RS28735 (N6B35_28735) 87761..88048 + 288 WP_263075342.1 hypothetical protein -
N6B35_RS28740 (N6B35_28740) 88225..88479 + 255 WP_263075343.1 hypothetical protein -
N6B35_RS28745 (N6B35_28745) 89335..89613 + 279 WP_263075344.1 hypothetical protein -
N6B35_RS28750 (N6B35_28750) 89669..90442 - 774 WP_263075345.1 nuclease-related domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..301524 301524


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-109)

Antitoxin

Antitoxin PemI-like

(5-80)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11927.82 Da        Isoelectric Point: 8.7208

>T259888 WP_263075339.1 NZ_CP106839:c86115-85783 [Klebsiella michiganensis]
MVKRYVPDAGDLIWIDFDPVAGHEQGGHRPAVVLSPFAYNNKVGLLLCVPCTTQIKGYPFEVTLSGSKEGVALSDQVTCV
DWRARKVTKKATVNSTELAEIRAKAKALIG

Download         Length: 333 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8757.12 Da        Isoelectric Point: 5.0176

>AT259888 WP_263075340.1 NZ_CP106839:c86360-86115 [Klebsiella michiganensis]
MAQAIVKKWGNSPSVRLPVAVMKAASLKVDDTVDIEVEDGRIIIVPVRQKEYSLDALLAGISTDNLHDKADFGPAQGKEL
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References