Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 75744..76654 Replicon plasmid unnamed
Accession NZ_CP106839
Organism Klebsiella michiganensis strain K5-3

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag N6B35_RS28675 Protein ID WP_263075333.1
Coordinates 76184..76654 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag N6B35_RS28670 Protein ID WP_004026357.1
Coordinates 75744..76187 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6B35_RS28635 (N6B35_28635) 70822..71211 + 390 WP_263075326.1 hypothetical protein -
N6B35_RS28640 (N6B35_28640) 71228..71635 + 408 WP_263075327.1 hypothetical protein -
N6B35_RS28645 (N6B35_28645) 71663..72130 + 468 WP_263075328.1 hypothetical protein -
N6B35_RS28650 (N6B35_28650) 72181..72579 + 399 WP_263075329.1 hypothetical protein -
N6B35_RS28655 (N6B35_28655) 72736..73167 + 432 WP_263075330.1 NB-ARC domain protein -
N6B35_RS28660 (N6B35_28660) 73950..74372 + 423 WP_263075331.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
N6B35_RS28665 (N6B35_28665) 74372..75643 + 1272 WP_263075332.1 translesion error-prone DNA polymerase V subunit UmuC -
N6B35_RS28670 (N6B35_28670) 75744..76187 + 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
N6B35_RS28675 (N6B35_28675) 76184..76654 + 471 WP_263075333.1 RES family NAD+ phosphorylase Toxin
N6B35_RS28680 (N6B35_28680) 76763..77023 - 261 WP_263075334.1 hypothetical protein -
N6B35_RS28685 (N6B35_28685) 77726..79101 + 1376 WP_263075335.1 IS3 family transposase -
N6B35_RS28690 (N6B35_28690) 79271..80311 + 1041 WP_263075336.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..301524 301524


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17501.76 Da        Isoelectric Point: 4.6155

>T259887 WP_263075333.1 NZ_CP106839:76184-76654 [Klebsiella michiganensis]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFSLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT259887 WP_004026357.1 NZ_CP106839:75744-76187 [Klebsiella michiganensis]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References