Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 75744..76654 | Replicon | plasmid unnamed |
| Accession | NZ_CP106839 | ||
| Organism | Klebsiella michiganensis strain K5-3 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | N6B35_RS28675 | Protein ID | WP_263075333.1 |
| Coordinates | 76184..76654 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A6P1V3Q9 |
| Locus tag | N6B35_RS28670 | Protein ID | WP_004026357.1 |
| Coordinates | 75744..76187 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| N6B35_RS28635 (N6B35_28635) | 70822..71211 | + | 390 | WP_263075326.1 | hypothetical protein | - |
| N6B35_RS28640 (N6B35_28640) | 71228..71635 | + | 408 | WP_263075327.1 | hypothetical protein | - |
| N6B35_RS28645 (N6B35_28645) | 71663..72130 | + | 468 | WP_263075328.1 | hypothetical protein | - |
| N6B35_RS28650 (N6B35_28650) | 72181..72579 | + | 399 | WP_263075329.1 | hypothetical protein | - |
| N6B35_RS28655 (N6B35_28655) | 72736..73167 | + | 432 | WP_263075330.1 | NB-ARC domain protein | - |
| N6B35_RS28660 (N6B35_28660) | 73950..74372 | + | 423 | WP_263075331.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| N6B35_RS28665 (N6B35_28665) | 74372..75643 | + | 1272 | WP_263075332.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| N6B35_RS28670 (N6B35_28670) | 75744..76187 | + | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin |
| N6B35_RS28675 (N6B35_28675) | 76184..76654 | + | 471 | WP_263075333.1 | RES family NAD+ phosphorylase | Toxin |
| N6B35_RS28680 (N6B35_28680) | 76763..77023 | - | 261 | WP_263075334.1 | hypothetical protein | - |
| N6B35_RS28685 (N6B35_28685) | 77726..79101 | + | 1376 | WP_263075335.1 | IS3 family transposase | - |
| N6B35_RS28690 (N6B35_28690) | 79271..80311 | + | 1041 | WP_263075336.1 | ATP-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..301524 | 301524 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17501.76 Da Isoelectric Point: 4.6155
>T259887 WP_263075333.1 NZ_CP106839:76184-76654 [Klebsiella michiganensis]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFSLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFSLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16480.80 Da Isoelectric Point: 10.2498
>AT259887 WP_004026357.1 NZ_CP106839:75744-76187 [Klebsiella michiganensis]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|