Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2868417..2869192 Replicon chromosome
Accession NZ_CP106838
Organism Klebsiella michiganensis strain K5-3

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0J2HI49
Locus tag N6B35_RS13615 Protein ID WP_032751262.1
Coordinates 2868707..2869192 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A0J2HGF0
Locus tag N6B35_RS13610 Protein ID WP_032751264.1
Coordinates 2868417..2868710 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6B35_RS13595 (N6B35_13595) 2863578..2864723 - 1146 WP_004854188.1 PLP-dependent aspartate aminotransferase family protein -
N6B35_RS13600 (N6B35_13600) 2864734..2866104 - 1371 WP_047722911.1 cystathionine beta-synthase -
N6B35_RS13605 (N6B35_13605) 2866650..2868038 + 1389 WP_032751266.1 DASS family sodium-coupled anion symporter -
N6B35_RS13610 (N6B35_13610) 2868417..2868710 + 294 WP_032751264.1 DUF1778 domain-containing protein Antitoxin
N6B35_RS13615 (N6B35_13615) 2868707..2869192 + 486 WP_032751262.1 GNAT family N-acetyltransferase Toxin
N6B35_RS13620 (N6B35_13620) 2869905..2870156 - 252 WP_071846062.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17523.45 Da        Isoelectric Point: 8.1567

>T259881 WP_032751262.1 NZ_CP106838:2868707-2869192 [Klebsiella michiganensis]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQLSGASRTFVCCHDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDRSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10960.59 Da        Isoelectric Point: 9.9171

>AT259881 WP_032751264.1 NZ_CP106838:2868417-2868710 [Klebsiella michiganensis]
MPAANSMAMKRETLNLRIRPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPAPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2HI49

Antitoxin

Source ID Structure
AlphaFold DB A0A0J2HGF0

References