Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 2868417..2869192 | Replicon | chromosome |
Accession | NZ_CP106838 | ||
Organism | Klebsiella michiganensis strain K5-3 |
Toxin (Protein)
Gene name | TacT2 | Uniprot ID | A0A0J2HI49 |
Locus tag | N6B35_RS13615 | Protein ID | WP_032751262.1 |
Coordinates | 2868707..2869192 (+) | Length | 162 a.a. |
Antitoxin (Protein)
Gene name | TacA2 | Uniprot ID | A0A0J2HGF0 |
Locus tag | N6B35_RS13610 | Protein ID | WP_032751264.1 |
Coordinates | 2868417..2868710 (+) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
N6B35_RS13595 (N6B35_13595) | 2863578..2864723 | - | 1146 | WP_004854188.1 | PLP-dependent aspartate aminotransferase family protein | - |
N6B35_RS13600 (N6B35_13600) | 2864734..2866104 | - | 1371 | WP_047722911.1 | cystathionine beta-synthase | - |
N6B35_RS13605 (N6B35_13605) | 2866650..2868038 | + | 1389 | WP_032751266.1 | DASS family sodium-coupled anion symporter | - |
N6B35_RS13610 (N6B35_13610) | 2868417..2868710 | + | 294 | WP_032751264.1 | DUF1778 domain-containing protein | Antitoxin |
N6B35_RS13615 (N6B35_13615) | 2868707..2869192 | + | 486 | WP_032751262.1 | GNAT family N-acetyltransferase | Toxin |
N6B35_RS13620 (N6B35_13620) | 2869905..2870156 | - | 252 | WP_071846062.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17523.45 Da Isoelectric Point: 8.1567
>T259881 WP_032751262.1 NZ_CP106838:2868707-2869192 [Klebsiella michiganensis]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQLSGASRTFVCCHDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDRSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLVN
A
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQLSGASRTFVCCHDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDRSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLVN
A
Download Length: 486 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0J2HI49 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0J2HGF0 |