Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 504746..505426 Replicon chromosome
Accession NZ_CP106838
Organism Klebsiella michiganensis strain K5-3

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag N6B35_RS02425 Protein ID WP_263074943.1
Coordinates 504746..505066 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag N6B35_RS02430 Protein ID WP_263074944.1
Coordinates 505103..505426 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6B35_RS02405 (N6B35_02405) 499973..502147 + 2175 WP_080528551.1 extracellular solute-binding protein -
N6B35_RS02410 (N6B35_02410) 502263..502556 - 294 WP_080528550.1 hypothetical protein -
N6B35_RS02415 (N6B35_02415) 502767..503249 - 483 WP_025107123.1 hypothetical protein -
N6B35_RS02420 (N6B35_02420) 503799..504632 - 834 WP_263075140.1 DUF4942 domain-containing protein -
N6B35_RS02425 (N6B35_02425) 504746..505066 - 321 WP_263074943.1 toxin Toxin
N6B35_RS02430 (N6B35_02430) 505103..505426 - 324 WP_263074944.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
N6B35_RS02435 (N6B35_02435) 505440..505910 - 471 WP_263074945.1 DNA repair protein RadC -
N6B35_RS02440 (N6B35_02440) 505980..506801 - 822 WP_263074947.1 DUF932 domain-containing protein -
N6B35_RS02445 (N6B35_02445) 506923..507354 - 432 WP_263075142.1 IrmA family protein -
N6B35_RS02450 (N6B35_02450) 507372..507824 - 453 WP_234054726.1 hypothetical protein -
N6B35_RS02455 (N6B35_02455) 507863..508429 - 567 WP_263074948.1 hypothetical protein -
N6B35_RS02460 (N6B35_02460) 508435..509136 - 702 WP_024484792.1 WYL domain-containing protein -
N6B35_RS02465 (N6B35_02465) 509349..510224 - 876 WP_263074950.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 503799..529874 26075


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(12-105)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12034.60 Da        Isoelectric Point: 5.9538

>T259876 WP_263074943.1 NZ_CP106838:c505066-504746 [Klebsiella michiganensis]
MHISSVPATVPASSRLSPIQVWQQLLTYLLEHHYGLTLNDTPFHDDTAIQEHIEAGITLADAVNFLVDRYELVRTDRKGF
SWQEQTPFLTATDILRARRATGLMNT

Download         Length: 321 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12013.60 Da        Isoelectric Point: 6.3160

>AT259876 WP_263074944.1 NZ_CP106838:c505426-505103 [Klebsiella michiganensis]
MPLTPPHEWGLQSDITPRFGARLVQEGNRLHYLADRAGLTGSFSPEQLQKLDQAFPLFIEQLENLLRSGEINPHHQHQVT
IQLAGLTCIADTRGSCGYVYISIYPTQ

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References