Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 799442..799971 Replicon chromosome
Accession NZ_CP106834
Organism Staphylococcus epidermidis strain AH6072

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag N8145_RS03740 Protein ID WP_001829891.1
Coordinates 799609..799971 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag N8145_RS03735 Protein ID WP_001829931.1
Coordinates 799442..799612 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8145_RS03710 (N8145_03710) 795266..795745 + 480 WP_002457111.1 PH domain-containing protein -
N8145_RS03715 (N8145_03715) 795738..797243 + 1506 WP_029376482.1 PH domain-containing protein -
N8145_RS03720 (N8145_03720) 797230..797739 + 510 WP_002457109.1 PH domain-containing protein -
N8145_RS03725 (N8145_03725) 797787..798140 + 354 WP_029376481.1 holo-ACP synthase -
N8145_RS03730 (N8145_03730) 798207..799355 + 1149 WP_002457107.1 alanine racemase -
N8145_RS03735 (N8145_03735) 799442..799612 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
N8145_RS03740 (N8145_03740) 799609..799971 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
N8145_RS03745 (N8145_03745) 800316..801317 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
N8145_RS03750 (N8145_03750) 801417..801743 + 327 WP_001829952.1 anti-sigma factor antagonist -
N8145_RS03755 (N8145_03755) 801745..802224 + 480 WP_001829903.1 anti-sigma B factor RsbW -
N8145_RS03760 (N8145_03760) 802199..802969 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T259870 WP_001829891.1 NZ_CP106834:799609-799971 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT259870 WP_001829931.1 NZ_CP106834:799442-799612 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References