Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 788257..788766 Replicon chromosome
Accession NZ_CP106834
Organism Staphylococcus epidermidis strain AH6072

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag N8145_RS03680 Protein ID WP_001829980.1
Coordinates 788557..788766 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag N8145_RS03675 Protein ID WP_001829893.1
Coordinates 788257..788550 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8145_RS03650 (N8145_03650) 783265..784053 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
N8145_RS03655 (N8145_03655) 784059..784697 + 639 WP_002505076.1 thiamine phosphate synthase -
N8145_RS03660 (N8145_03660) 784786..785658 + 873 WP_002458703.1 membrane protein insertase YidC -
N8145_RS03665 (N8145_03665) 785764..786417 - 654 WP_001829983.1 HD domain-containing protein -
N8145_RS03670 (N8145_03670) 786599..788083 - 1485 WP_002457116.1 cardiolipin synthase -
N8145_RS03675 (N8145_03675) 788257..788550 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
N8145_RS03680 (N8145_03680) 788557..788766 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
N8145_RS03685 (N8145_03685) 788909..789046 + 138 WP_001829949.1 Lmo0850 family protein -
N8145_RS03690 (N8145_03690) 789145..790356 - 1212 WP_002486299.1 FtsW/RodA/SpoVE family cell cycle protein -
N8145_RS03695 (N8145_03695) 790747..791820 + 1074 WP_002468311.1 D-alanine--D-alanine ligase -
N8145_RS03700 (N8145_03700) 791832..793187 + 1356 WP_002470674.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T259869 WP_001829980.1 NZ_CP106834:788557-788766 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT259869 WP_001829893.1 NZ_CP106834:788257-788550 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References