Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 656663..657318 Replicon chromosome
Accession NZ_CP106824
Organism Neisseria gonorrhoeae strain 9399

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag NDL70_RS03525 Protein ID WP_003691083.1
Coordinates 656899..657318 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag NDL70_RS03520 Protein ID WP_003688410.1
Coordinates 656663..656899 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDL70_RS03490 (NDL70_03490) 651798..652085 + 288 WP_003688407.1 hypothetical protein -
NDL70_RS03495 (NDL70_03495) 652157..653323 + 1167 WP_003699872.1 ADP-forming succinate--CoA ligase subunit beta -
NDL70_RS03500 (NDL70_03500) 653334..654224 + 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
NDL70_RS03505 (NDL70_03505) 654607..654993 - 387 Protein_684 transposase -
NDL70_RS03510 (NDL70_03510) 655232..655633 + 402 WP_020996834.1 helix-turn-helix domain-containing protein -
NDL70_RS03515 (NDL70_03515) 655638..656216 + 579 WP_003697246.1 IS3 family transposase -
NDL70_RS03520 (NDL70_03520) 656663..656899 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
NDL70_RS03525 (NDL70_03525) 656899..657318 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
NDL70_RS03530 (NDL70_03530) 657467..658921 - 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
NDL70_RS03535 (NDL70_03535) 658918..659619 - 702 WP_003688414.1 lactate utilization protein C -
NDL70_RS03540 (NDL70_03540) 659616..660395 - 780 WP_003688416.1 (Fe-S)-binding protein -
NDL70_RS03545 (NDL70_03545) 660543..662084 + 1542 WP_003691084.1 MDR family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T259863 WP_003691083.1 NZ_CP106824:656899-657318 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT259863 WP_003688410.1 NZ_CP106824:656663-656899 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References