Detailed information of TA system TA259862

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): omega-epsilon-zeta/zeta(toxin)
• Location: 16039..17690
• Replicon: plasmid pConjugative
• Accession: NZ_CP106822
• Organism: Neisseria gonorrhoeae strain 10529

Toxin (Protein)

• Gene name: ng_zeta1
• Uniprot ID: -
• Locus tag: NDQ80_RS11770
• Protein ID: WP_033911112.1
• Coordinates: 16039..17244 (+)
• Length: 402 a.a.

Antitoxin (Protein)

• Gene name: ng_epsilon1
• Uniprot ID: D5K9G8
• Locus tag: NDQ80_RS11775
• Protein ID: WP_003701903.1
• Coordinates: 17259..17690 (+)
• Length: 144 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NDQ80_RS11735 (NDQ80_11750)	11681..11995	+	315	WP_082295984.1	hypothetical protein	-
NDQ80_RS11740 (NDQ80_11755)	12009..12350	+	342	WP_013085576.1	hypothetical protein	-
NDQ80_RS11745 (NDQ80_11760)	12354..13250	+	897	WP_003701917.1	hypothetical protein	-
NDQ80_RS11750 (NDQ80_11765)	13402..13875	-	474	WP_206692149.1	hypothetical protein	-
NDQ80_RS11755 (NDQ80_11770)	14360..14608	+	249	WP_014580056.1	hypothetical protein	-
NDQ80_RS11760 (NDQ80_11775)	14605..15813	+	1209	WP_014580057.1	zeta toxin family protein	-
NDQ80_RS11765 (NDQ80_11780)	15847..16032	+	186	WP_014580058.1	hypothetical protein	-
NDQ80_RS11770 (NDQ80_11785)	16039..17244	+	1206	WP_033911112.1	zeta toxin family protein	Toxin
NDQ80_RS11775 (NDQ80_11790)	17259..17690	+	432	WP_003701903.1	hypothetical protein	Antitoxin
NDQ80_RS11780 (NDQ80_11795)	17742..18296	+	555	WP_003701901.1	recombinase family protein	-
NDQ80_RS11785 (NDQ80_11800)	18406..18696	-	291	WP_003701899.1	virulence factor	-
NDQ80_RS11790 (NDQ80_11805)	18799..19398	-	600	WP_003701898.1	TrbN protein	-
NDQ80_RS11795 (NDQ80_11810)	19398..19970	-	573	WP_226888038.1	TrbM/KikA/MpfK family conjugal transfer protein	-
NDQ80_RS11800 (NDQ80_11815)	19963..21570	-	1608	WP_263070473.1	P-type conjugative transfer protein TrbL	-
NDQ80_RS11805 (NDQ80_11820)	21805..22581	-	777	WP_260244450.1	P-type conjugative transfer protein TrbJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..39054	39054

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• KfrB domain (284-343)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 402 a.a.
• Molecular weight: 44747.59 Da
• Isoelectric Point: 7.2930

>T259862 WP_033911112.1 NZ_CP106822:16039-17244 [Neisseria gonorrhoeae]
MVKLSSDINLRDFGNNEYLSSVQDEAIRFATEQTDEILSLYSQHADTEGGRYVCADTFKELFPAFENKEDRATVNNAIHN
SAAVLSSTQFDEVLKRDEPQKKEVIFVTGIPGSGKTSTVKNMMMQDTTKLLFEGQLARPQSAFRKIEQCLERNLEVTIVA
VSMRAERASDNTYKRFNEYGREASIGIMADIQANLPDGLKQIRDKFGDAVKIVGINQDRNSEFIDKFDDVIKMLSLGSQE
QILGRLAEKIQSDFDSGKISRECFNQAKGSMDLESVFAKKEYSQQRVVTNSKGVTLETKSANELWSKVEQIPVTGMKAGI
YLLGQAKKAETGQTYSGEIIYKDAAAVFQKTKNGLVRHNATHNEERLAKLVEIGQNVSIGSNKGKLIVKSLEYSAKKSIS
R

Nucleotide

• Length: 1206 bp

Antitoxin

Protein

• Length: 144 a.a.
• Molecular weight: 15927.05 Da
• Isoelectric Point: 4.4211

>AT259862 WP_003701903.1 NZ_CP106822:17259-17690 [Neisseria gonorrhoeae]
MKEKMRLITEISLIIRELSYSRRGYRPESYAAALDNLTIIGDLADILHNIEAATGNPFVQRMVDEKLRKFVTDFPAYKVR
LSPFLNGCPHDLSLGAESLGKGESIADALAVPPEEVDIADIEFDRVLIEDDRWTGAYDGGNAQ

Nucleotide

• Length: 432 bp

Structures

Antitoxin

• AlphaFold DB: D5K9G8