Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 950330..950985 Replicon chromosome
Accession NZ_CP106821
Organism Neisseria gonorrhoeae strain 10529

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag NDQ80_RS04910 Protein ID WP_003691083.1
Coordinates 950330..950749 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag NDQ80_RS04915 Protein ID WP_003688410.1
Coordinates 950749..950985 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDQ80_RS04890 (NDQ80_04905) 945564..947105 - 1542 WP_003691084.1 MDR family MFS transporter -
NDQ80_RS04895 (NDQ80_04910) 947253..948032 + 780 WP_003688416.1 (Fe-S)-binding protein -
NDQ80_RS04900 (NDQ80_04915) 948029..948730 + 702 WP_003688414.1 lactate utilization protein C -
NDQ80_RS04905 (NDQ80_04920) 948727..950181 + 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
NDQ80_RS04910 (NDQ80_04925) 950330..950749 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
NDQ80_RS04915 (NDQ80_04930) 950749..950985 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
NDQ80_RS04920 (NDQ80_04935) 951432..952010 - 579 WP_003697246.1 IS3 family transposase -
NDQ80_RS04925 (NDQ80_04940) 952015..952305 - 291 WP_047917062.1 helix-turn-helix domain-containing protein -
NDQ80_RS04930 (NDQ80_04945) 952655..953041 + 387 Protein_968 transposase -
NDQ80_RS04935 (NDQ80_04950) 953424..954314 - 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
NDQ80_RS04940 (NDQ80_04955) 954325..955491 - 1167 WP_003699872.1 ADP-forming succinate--CoA ligase subunit beta -
NDQ80_RS04945 (NDQ80_04960) 955563..955850 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T259860 WP_003691083.1 NZ_CP106821:c950749-950330 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT259860 WP_003688410.1 NZ_CP106821:c950985-950749 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References