Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 1412..1875 Replicon plasmid pJD1
Accession NZ_CP106820
Organism Neisseria gonorrhoeae strain 10791

Toxin (Protein)


Gene name VapD Uniprot ID Q51003
Locus tag LLE39_RS11720 Protein ID WP_003690225.1
Coordinates 1597..1875 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q51002
Locus tag LLE39_RS11715 Protein ID WP_003690223.1
Coordinates 1412..1597 (+) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE39_RS11700 (LLE39_11700) 52..921 + 870 WP_003690219.1 replication initiation protein -
LLE39_RS11705 (LLE39_11705) 925..1167 + 243 WP_003690220.1 HTH domain-containing protein -
LLE39_RS11710 (LLE39_11710) 1164..1409 + 246 WP_003690221.1 hypothetical protein -
LLE39_RS11715 (LLE39_11715) 1412..1597 + 186 WP_003690223.1 DUF5397 family protein Antitoxin
LLE39_RS11720 (LLE39_11720) 1597..1875 + 279 WP_003690225.1 endoribonuclease VapD Toxin
LLE39_RS11725 (LLE39_11725) 1853..2107 - 255 WP_003690227.1 Cryptic plasmid protein A -
LLE39_RS11730 (LLE39_11730) 2154..2795 - 642 WP_003690229.1 MbeB family mobilization protein -
LLE39_RS11735 (LLE39_11735) 2879..3508 - 630 WP_003696452.1 relaxase/mobilization nuclease domain-containing protein -
LLE39_RS11740 (LLE39_11740) 3493..3873 - 381 WP_014580441.1 MobC family plasmid mobilization relaxosome protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..4207 4207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(2-60)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10473.89 Da        Isoelectric Point: 6.9726

>T259859 WP_003690225.1 NZ_CP106820:1597-1875 [Neisseria gonorrhoeae]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTRIQGSLYTCQNEDMANLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6717.54 Da        Isoelectric Point: 4.2641

>AT259859 WP_003690223.1 NZ_CP106820:1412-1597 [Neisseria gonorrhoeae]
MQTTIPTGSIRTFGDYGVMYIVGTPAEQLPDGDWLVNIELPESGEHTQYKLSHIVQDPKAA

Download         Length: 186 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H5FJI5

Antitoxin

Source ID Structure
AlphaFold DB Q51002

References