Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 651623..652278 Replicon chromosome
Accession NZ_CP106817
Organism Neisseria gonorrhoeae strain 10574

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LLE36_RS03485 Protein ID WP_229931500.1
Coordinates 651859..652278 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag LLE36_RS03480 Protein ID WP_003688410.1
Coordinates 651623..651859 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE36_RS03450 (LLE36_03450) 646758..647045 + 288 WP_003688407.1 hypothetical protein -
LLE36_RS03455 (LLE36_03455) 647117..648283 + 1167 WP_003699872.1 ADP-forming succinate--CoA ligase subunit beta -
LLE36_RS03460 (LLE36_03460) 648294..649184 + 891 WP_229931474.1 succinate--CoA ligase subunit alpha -
LLE36_RS03465 (LLE36_03465) 649567..649953 - 387 Protein_676 transposase -
LLE36_RS03470 (LLE36_03470) 650303..650593 + 291 WP_047917062.1 helix-turn-helix domain-containing protein -
LLE36_RS03475 (LLE36_03475) 650598..651176 + 579 WP_003697246.1 IS3 family transposase -
LLE36_RS03480 (LLE36_03480) 651623..651859 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
LLE36_RS03485 (LLE36_03485) 651859..652278 + 420 WP_229931500.1 type II toxin-antitoxin system toxin FitB Toxin
LLE36_RS03490 (LLE36_03490) 652427..653881 - 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
LLE36_RS03495 (LLE36_03495) 653878..654579 - 702 WP_003688414.1 lactate utilization protein C -
LLE36_RS03500 (LLE36_03500) 654576..655355 - 780 WP_003688416.1 (Fe-S)-binding protein -
LLE36_RS03505 (LLE36_03505) 655503..657044 + 1542 WP_003691084.1 MDR family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 649501..649974 473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15336.67 Da        Isoelectric Point: 5.5742

>T259855 WP_229931500.1 NZ_CP106817:651859-652278 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGWILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT259855 WP_003688410.1 NZ_CP106817:651623-651859 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References