Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 652247..652902 Replicon chromosome
Accession NZ_CP106811
Organism Neisseria gonorrhoeae strain 10531

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag OCL46_RS03485 Protein ID WP_003691083.1
Coordinates 652483..652902 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag OCL46_RS03480 Protein ID WP_003688410.1
Coordinates 652247..652483 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCL46_RS03450 (OCL46_03450) 647382..647669 + 288 WP_003688407.1 hypothetical protein -
OCL46_RS03455 (OCL46_03455) 647741..648907 + 1167 WP_003699872.1 ADP-forming succinate--CoA ligase subunit beta -
OCL46_RS03460 (OCL46_03460) 648918..649808 + 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
OCL46_RS03465 (OCL46_03465) 650191..650577 - 387 Protein_676 transposase -
OCL46_RS03470 (OCL46_03470) 650816..651217 + 402 WP_020996834.1 helix-turn-helix domain-containing protein -
OCL46_RS03475 (OCL46_03475) 651222..651800 + 579 WP_003697246.1 IS3 family transposase -
OCL46_RS03480 (OCL46_03480) 652247..652483 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
OCL46_RS03485 (OCL46_03485) 652483..652902 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
OCL46_RS03490 (OCL46_03490) 653051..654505 - 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
OCL46_RS03495 (OCL46_03495) 654502..655203 - 702 WP_003688414.1 lactate utilization protein C -
OCL46_RS03500 (OCL46_03500) 655200..655979 - 780 WP_003688416.1 (Fe-S)-binding protein -
OCL46_RS03505 (OCL46_03505) 656127..657668 + 1542 WP_003691084.1 MDR family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T259847 WP_003691083.1 NZ_CP106811:652483-652902 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT259847 WP_003688410.1 NZ_CP106811:652247-652483 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References